TNF Receptor II Antibody | MyBioSource MBS853986 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

TNF Receptor II Antibody

catalog :

MBS853986

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS853986

products type :

Antibody

products full name :

TNF Receptor II Antibody

products short name :

TNF Receptor II

products name syn :

Tumor necrosis factor receptor superfamily member 1B [Precursor]; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; p75; p80 TNF-alpha receptor; CD120b antigen; Etanercept; Tumor necrosis factor receptor superfamily member 1b; membrane form; Tumor necrosis factor-binding protein 2; TNFRSF1B; TNFBR; TNFR2

other names :

tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily member 1B; TNF-R2; TNF-RII; p75 TNF receptor; p80 TNF-alpha receptor; soluble TNFR1B variant 1; tumor necrosis factor receptor 2; tumor necrosis factor beta receptor; tumor necrosis factor receptor type II; tumor necrosis factor binding protein 2; tumor necrosis factor receptor superfamily, member 1B; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; CD_antigen: CD120b; INN: EtanerceptCleaved into the following 2 chains:Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2Alternative name(s):TBP-2; TBPII

other gene names :

TNFRSF1B; TNFRSF1B; p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II; TNFBR; TNFR2; TNF-R2; TNF-RII; TNFR-II

uniprot entry name :

TNR1B_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

461

specificity :

TNF Receptor II antibody detects endogenous levels of total TNF Receptor II protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)

app notes :

WB: 1:500~1:1000, IF: 1:100~1:500, ELISA: 1:20000

other info2 :

Immunogen: The antiserum was produced against synthesized peptide derived from C-terminal of human TNF Receptor II. Pathway: Receptors

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Smith C.A., Science 248:1019-1023(1990). Kohno T., Proc. Natl. Acad. Sci. U.S.A. 87:8331-8335(1990). Beltinger C.P., Genomics 35:94-100(1996). ------------------------------------------------------------------------------------------------------------------------------------------

ncbi gi num :

4507577

ncbi acc num :

NP_001057.1

ncbi gb acc num :

NM_001066.2

uniprot acc num :

P20333

ncbi mol weight :

28,461 Da

ncbi pathways :

Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Apoptosis Pathway (198797); Apoptosis Modulation And Signaling Pathway (198822); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); IL-3 Signaling Pathway (198881); Inflammatory Response Pathway (198766)

ncbi summary :

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]

uniprot summary :

TNF-R2: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. Binds to TRAF2. Interacts with BMX. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, cytokine; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1p36.22. Cellular Component: cell soma; perinuclear region of cytoplasm; integral to membrane; plasma membrane; extracellular region; nucleus; lipid raft. Molecular Function: protein binding; tumor necrosis factor receptor activity; ubiquitin protein ligase binding. Biological Process: tumor necrosis factor-mediated signaling pathway; DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of inflammatory response; immune response; RNA destabilization; inflammatory response; positive regulation of membrane protein ectodomain proteolysis; aging

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage