product summary
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company name :
MyBioSource
product type :
antibody
product name :
ARHGEF3 Antibody
catalog :
MBS853980
quantity :
0.1 mg
price :
215 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS853980
products type :
Antibody
products full name :
ARHGEF3 Antibody
products short name :
ARHGEF3
products name syn :
ARHG3; DKFZP434F2429; exchange factor found in platelets and leukemic and neuronal tissues; GEF3; MGC118905; Rho guanine nucleotide exchange factor 3; STA3; XPLN
other names :
rho guanine nucleotide exchange factor 3 isoform 1; Rho guanine nucleotide exchange factor 3; rho guanine nucleotide exchange factor 3; RhoGEF protein; 59.8 kDA protein; exchange factor found in platelets and leukemic and neuronal tissues, XPLN; Rho guanine nucleotide exchange factor (GEF) 3; Exchange factor found in platelets and leukemic and neuronal tissues; XPLN
products gene name :
ARHGEF3
other gene names :
ARHGEF3; ARHGEF3; GEF3; STA3; XPLN; XPLN
uniprot entry name :
ARHG3_HUMAN
host :
Rabbit
reactivity :
Human, Mouse
sequence length :
558
specificity :
ARHGEF3 antibody detects endogenous levels of total ARHGEF3 protein.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
concentration :
1mg/ml
storage stability :
Store at -20 degree C for 1 year
tested application :
Western Blot (WB), ELISA (EIA)
app notes :
WB: 1:500~1:1000, ELISA: 1:5000
other info2 :
Immunogen: The antiserum was produced against synthesized peptide derived from internal of human ARHGEF3. Pathway: GTP-binding
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
Thiesen S., Biochem. Biophys. Res. Commun. 273:364-369(2000). Wiemann S., Genome Res. 11:422-435(2001). Guo J.H., Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
ncbi gi num :
190885495
ncbi acc num :
NP_001122087.1
ncbi gb acc num :
NM_001128615.1
uniprot acc num :
Q9NR81
ncbi mol weight :
36,981 Da
ncbi pathways :
Cell Death Signalling Via NRAGE, NRIF And NADE Pathway (106443); G Alpha (12/13) Signalling Events Pathway (106041); GPCR Downstream Signaling Pathway (119548); NRAGE Signals Death Through JNK Pathway (106444); Regulation Of RhoA Activity Pathway (138070); Rho GTPase Cycle Pathway (106503); Signal Transduction Pathway (477114); Signaling By GPCR Pathway (106356); Signaling By Rho GTPases Pathway (106502); Signalling By NGF Pathway (106439)
ncbi summary :
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
uniprot summary :
ARHGEF3: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. 4 isoforms of the human protein are produced by alternative splicing. Protein type: GAPs, Rac/Rho; Motility/polarity/chemotaxis; GAPs. Chromosomal Location of Human Ortholog: 3p14.3. Cellular Component: intracellular; cytosol. Molecular Function: Rho guanyl-nucleotide exchange factor activity. Biological Process: regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction; Rho protein signal transduction
size1 :
0.1 mg
price1 :
215 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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