Cytochrome P450 26A1 Antibody | MyBioSource MBS853966 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Cytochrome P450 26A1 Antibody

catalog :

MBS853966

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS853966

products type :

Antibody

products full name :

Cytochrome P450 26A1 Antibody

products short name :

Cytochrome P450 26A1

products name syn :

Cytochrome P450 26A1; EC 1.14.-.-; Retinoic acid-metabolizing cytochrome; P450 retinoic acid-inactivating 1; P450RAI; hP450RAI; Retinoic acid 4-hydroxylase; CYP26; P450RAI1; CP26A

other names :

cytochrome P450 26A1 isoform 1; Cytochrome P450 26A1; cytochrome P450 26A1; hP450RAI; cytochrome P450RAI; retinoic acid 4-hydroxylase; P450, retinoic acid-inactivating, 1; retinoic acid-metabolizing cytochrome; cytochrome P450 retinoic acid-inactivating 1; cytochrome P450, subfamily XXVIA, polypeptide 1; cytochrome P450, family 26, subfamily A, polypeptide 1; Cytochrome P450 retinoic acid-inactivating 1; Cytochrome P450RAI; hP450RAI; Retinoic acid 4-hydroxylase; Retinoic acid-metabolizing cytochrome

other gene names :

CYP26A1; CYP26A1; CP26; CYP26; P450RAI; P450RAI1; CYP26; P450RAI1; Cytochrome P450RAI; hP450RAI

uniprot entry name :

CP26A_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

497

specificity :

Cytochrome P450 26A1 antibody detects endogenous levels of total Cytochrome P450 26A1 protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB: 1:500~1:1000, ELISA: 1:20000

other info2 :

Immunogen: The antiserum was produced against synthesized peptide derived from internal of human Cytochrome P450 26A1. Pathway: Translation

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

White J.A., J. Biol. Chem. 272:18538-18541(1997). Sonneveld E., Cell Growth Differ. 9:629-637(1998). ova-Griffin M.E., Biochem. Biophys. Res. Commun. 252:487-491(1998). -----------------------------------------------------------------------------------------------------------------------------------------

ncbi gi num :

16933530

ncbi acc num :

NP_000774.2

ncbi gb acc num :

NM_000783.3

uniprot acc num :

O43174

ncbi mol weight :

48,558 Da

ncbi pathways :

Adipogenesis Pathway (198832); Biological Oxidations Pathway (105698); Cytochrome P450 - Arranged By Substrate Type Pathway (105700); Metabolic Pathways (132956); Metabolism Pathway (477135); Nuclear Receptors In Lipid Metabolism And Toxicity Pathway (198887); Phase 1 - Functionalization Of Compounds Pathway (105699); Retinol Metabolism Pathway (83020); Retinol Metabolism Pathway (406); Vitamin A And Carotenoid Metabolism Pathway (920901)

ncbi summary :

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

uniprot summary :

CYP26A1: Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA. Belongs to the cytochrome P450 family. Protein type: Cofactor and Vitamin Metabolism - retinol; Endoplasmic reticulum; EC 1.14.-.-; Oxidoreductase. Chromosomal Location of Human Ortholog: 10q23-q24. Cellular Component: endoplasmic reticulum membrane. Molecular Function: retinoic acid binding; iron ion binding; retinoic acid 4-hydroxylase activity; heme binding; oxygen binding. Biological Process: anterior/posterior pattern formation; retinoic acid receptor signaling pathway; negative regulation of retinoic acid receptor signaling pathway; vitamin metabolic process; central nervous system development; neural crest cell development; metabolic process; xenobiotic metabolic process

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage