ABCG5 Antibody | MyBioSource MBS853944 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ABCG5 Antibody

catalog :

MBS853944

quantity :

0.1 mg

price :

290 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS853944

products type :

Antibody

products full name :

ABCG5 Antibody

products short name :

ABCG5

other names :

ATP-binding cassette sub-family G member 5; ATP-binding cassette sub-family G member 5; ATP-binding cassette sub-family G member 5; sterolin 1; sterolin-1; ATP-binding cassette, subfamily G, member 5; ATP-binding cassette, sub-family G (WHITE), member 5; Sterolin-1

products gene name :

ABCG5

other gene names :

ABCG5; ABCG5; STSL

uniprot entry name :

ABCG5_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

651

form :

Lyophilized anti-ABCG5 antibody purified by peptide affinity column containing 1% BSA and 0.02% NaN3

concentration :

100ug/200ul

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

Peptide ELISA titer: 1:5,000-1:10,000. Western blot analysis: 1:1,000-1:2,000. Optimal dilutions/concentrations should be determined by the end user.

other info1 :

Source Note: Rabbit polyclonal ABCG5 (1) antibody was raised against a peptide from intermediate residues of human ABCG5 protein. Reactivity Note: Not yet tested in other species.

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

(1) Peloso,G.M., Demissie,S., Collins,D., et al. Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease. J. Lipid Res. 51 (12), 3524-3532 (2010)

ncbi gi num :

11967969

ncbi acc num :

NP_071881.1

ncbi gb acc num :

NM_022436.2

ncbi mol weight :

28,480 Da

ncbi pathways :

ABC Transporters Pathway (83035); ABC Transporters Pathway (436); ABC-family Proteins Mediated Transport Pathway (106573); ABCA Transporters In Lipid Homeostasis Pathway (477112); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Fat Digestion And Absorption Pathway (194385); Fat Digestion And Absorption Pathway (194324); Lipid Digestion, Mobilization, And Transport Pathway (106111); Metabolism Pathway (477135)

ncbi summary :

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008]

uniprot summary :

ABCG5: Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Defects in ABCG5 are a cause of sitosterolemia (STSL); also known as phytosterolemia or shellfish sterolemia. It is a rare autosomal recessive disorder characterized by increased intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and decreased biliary excretion of dietary sterols into bile. Sitosterolemia patients have hypercholesterolemia, very high levels of plant sterols in the plasma, and frequently develop tendon and tuberous xanthomas, accelerated atherosclerosis and premature coronary artery disease. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. Protein type: Membrane protein, integral; Transporter, ABC family; Membrane protein, multi-pass; Transporter. Chromosomal Location of Human Ortholog: 2p21. Cellular Component: apical plasma membrane; plasma membrane; ATP-binding cassette (ABC) transporter complex; receptor complex. Molecular Function: protein binding; protein heterodimerization activity; cholesterol transporter activity; ATPase activity; ATP binding. Biological Process: response to drug; negative regulation of cholesterol absorption; cholesterol homeostasis; cholesterol absorption; cholesterol efflux; response to ionizing radiation; excretion; transmembrane transport; response to nutrient; sterol transport. Disease: Sitosterolemia

size1 :

0.1 mg

price1 :

290 USD

more info or order :

MyBioSource product webpage