LAMB1 Antibody | MyBioSource MBS853645 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

LAMB1 Antibody

catalog :

MBS853645

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS853645

products type :

Antibody

products full name :

LAMB1 Antibody

products short name :

LAMB1

products name syn :

Laminin subunit beta-1 [Precursor]; Laminin B1 chain; LAMB1

other names :

laminin subunit beta-1; Laminin subunit beta-1; laminin subunit beta-1; laminin B1 chain; laminin, beta 1; Laminin B1 chain; Laminin-1 subunit beta; Laminin-10 subunit beta; Laminin-12 subunit beta; Laminin-2 subunit beta; Laminin-6 subunit beta; Laminin-8 subunit beta

products gene name :

LAMB1

other gene names :

LAMB1; LAMB1; CLM; LIS5

uniprot entry name :

LAMB1_HUMAN

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

1786

specificity :

LAMB1 antibody detects endogenous levels of total LAMB1 protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100, IF: 1:100~1:500, ELISA: 1:10000

other info2 :

Immunogen: The antiserum was produced against synthesized peptide derived from C-terminal of human LAMB1. Pathway: Adhesion

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Vuolteenaho R., J. Biol. Chem. 265:15611-15616(1990). Pikkarainen T., J. Biol. Chem. 262:10454-10462(1987). Scherer S.W., Science 300:767-772(2003). ------------------------------------------------------------------------------------------------------------------------------------------

ncbi gi num :

167614504

ncbi acc num :

NP_002282.2

ncbi gb acc num :

NM_002291.2

uniprot acc num :

P07942

ncbi mol weight :

198,038 Da

ncbi pathways :

Alpha6-Beta4 Integrin Signaling Pathway (198807); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Axon Guidance Pathway (105688); Degradation Of The Extracellular Matrix Pathway (576263); Developmental Biology Pathway (477129); ECM Proteoglycans Pathway (833812); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Extracellular Matrix Organization Pathway (576262)

ncbi summary :

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq, Aug 2011]

uniprot summary :

LAMB1: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 7q22. Cellular Component: extracellular matrix; extracellular space; laminin-8 complex; laminin-2 complex; laminin-1 complex; perinuclear region of cytoplasm; laminin-10 complex; extracellular region; basement membrane. Molecular Function: integrin binding; enzyme binding; extracellular matrix structural constituent; structural molecule activity; glycosphingolipid binding. Biological Process: odontogenesis; axon guidance; extracellular matrix disassembly; extracellular matrix organization and biogenesis; neuronal-glial interaction involved in cerebral cortex radial glia guided migration; negative regulation of cell adhesion; cell adhesion; embryo implantation; neurite development; positive regulation of epithelial cell proliferation; positive regulation of cell migration. Disease: Lissencephaly 5

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage