NR0B2 Antibody | MyBioSource MBS853642 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

NR0B2 Antibody

catalog :

MBS853642

quantity :

0.1 mg

price :

290 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS853642

products type :

Antibody

products full name :

NR0B2 Antibody

products short name :

NR0B2

other names :

nuclear receptor subfamily 0 group B member 2; Nuclear receptor subfamily 0 group B member 2; nuclear receptor subfamily 0 group B member 2; nuclear receptor SHP; small heterodimer partner; orphan nuclear receptor SHP; nuclear receptor subfamily 0, group B, member 2; Orphan nuclear receptor SHP; Small heterodimer partner

products gene name :

NR0B2

other gene names :

NR0B2; NR0B2; SHP; SHP1; SHP

uniprot entry name :

NR0B2_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

257

form :

Lyophilized NR0B2 antibody purified by protein A column containing 0.02% NaN3

concentration :

100ug/200ul

tested application :

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)

app notes :

ELISA titer: 1:20,000-1:80,000. Western blot analysis: 1:500-1:1,000. Immunohistochemistry: 1:100-1:500. Optimal dilutions/concentrations should be determined by the end user.

other info1 :

Source Note: Rabbit polyclonal NR0B2 (1) antibody was raised against a recombinate human NR0B2 protein 1-243aa (BC030207). Reactivity Note: Predicted: Mouse, Rat; Not yet tested in other species.

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

(1) He,C., Kraft,P., Chasman,D.I., et al. A large-scale candidate gene association study of age at menarche and age at natural menopause. Hum. Genet. 128 (5), 515-527 (2010)

ncbi gi num :

13259503

ncbi acc num :

NP_068804.1

ncbi gb acc num :

NM_021969.2

ncbi mol weight :

28,058 Da

ncbi pathways :

Androgen Receptor Signaling Pathway (198806); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Nuclear Receptor Transcription Pathway (105979)

ncbi summary :

The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]

uniprot summary :

NR0B2: Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1. Defects in NR0B2 may be associated with obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Belongs to the nuclear hormone receptor family. NR0 subfamily. Protein type: Nuclear receptor; Nuclear receptor co-regulator; Transcription, coactivator/corepressor. Chromosomal Location of Human Ortholog: 1p36.1. Cellular Component: nucleoplasm; protein complex; cytoplasm; nucleus. Molecular Function: retinoid X receptor binding; protein domain specific binding; peroxisome proliferator activated receptor binding; protein binding; protein homodimerization activity; DNA binding; protein complex binding; steroid hormone receptor activity; thyroid hormone receptor binding; transcription corepressor activity; transcription factor activity. Biological Process: transcription initiation from RNA polymerase II promoter; cholesterol metabolic process; organ regeneration; negative regulation of transcription factor activity; response to glucose stimulus; positive regulation of insulin secretion; gene expression; steroid hormone mediated signaling; negative regulation of transcription from RNA polymerase II promoter. Disease: Obesity

size1 :

0.1 mg

price1 :

290 USD

more info or order :

MyBioSource product webpage