catalog number :
MBS8535744
products full name :
PROCR
products short name :
[PROCR]
products name syn :
[CCCA; CCD41; EPCR]
other names :
[endothelial protein C receptor; Endothelial protein C receptor; endothelial protein C receptor; protein C receptor; Activated protein C receptor; APC receptor; Endothelial cell protein C receptor; CD_antigen: CD201]
products gene name :
[PROCR]
other gene names :
[PROCR; PROCR; CCCA; EPCR; CCD41; EPCR; APC receptor]
reactivity :
Human, Mouse, Rat
purity :
Affinity purification
form :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
storage stability :
Store at -20°C. Avoid repeated freeze/thaw cycles.
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
WB: 1:500-1:2000. IHC: 1:50-1:200
other info1 :
Immunogen: Recombinant protein of human PROCR
products description :
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer.
ncbi acc num :
NP_006395.2
ncbi gb acc num :
NM_006404.4
ncbi pathways :
Cell Surface Interactions At The Vascular Wall Pathway (1269373); Common Pathway Of Fibrin Clot Formation (1269371); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Formation Of Fibrin Clot (Clotting Cascade) Pathway (1269368); Hemostasis Pathway (1269340)
ncbi summary :
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]
uniprot summary :
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.