HCK (Phospho-Tyr521) Antibody | MyBioSource MBS853534 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

HCK (Phospho-Tyr521) Antibody

catalog :

MBS853534

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS853534

products type :

Antibody

products full name :

HCK (Phospho-Tyr521) Antibody

products short name :

HCK

products name syn :

Tyrosine-protein kinase HCK; EC=2.7.10.2; Hemopoietic cell kinase; p59-HCK/p60-HCK

other names :

tyrosine-protein kinase HCK isoform b; Tyrosine-protein kinase HCK; tyrosine-protein kinase HCK; p59-HCK/p60-HCK; hemopoietic cell kinase; hematopoietic cell kinase; HCK proto-oncogene, Src family tyrosine kinase; Hematopoietic cell kinase; Hemopoietic cell kinase; p59-HCK/p60-HCK; p59Hck; p61Hck

products gene name :

HCK

other gene names :

HCK; HCK; JTK9; p59Hck; p61Hck

uniprot entry name :

HCK_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

505

specificity :

HCK (Phospho-Tyr521) antibody detects endogenous levels of HCK only when phosphorylated at tyrosine 521.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation s

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB: 1:500~1:1000, ELISA: 1:10000

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human HCK around the phosphorylation site of tyrosine 521. All Sites: Human: Tyr522; Mouse: Tyr520; Rat: Tyr520. Pathway: Phospho-specific

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Quintrell N., Mol. Cell. Biol. 7:2267-2275(1987) [PubMed: 3496523]. Ziegler S.F.,Mol. Cell. Biol. 7:2276-2285(1987) [PubMed: 3453117]. Ota T., Nat. Genet. 36:40-45(2004) [PubMed: 14702039]. ----------------------------------------------------------------------------

ncbi gi num :

287326139

ncbi acc num :

NP_001165600.1

ncbi gb acc num :

NM_001172129.1

uniprot acc num :

P08631

ncbi mol weight :

59,529 Da

ncbi pathways :

Alpha-synuclein Signaling Pathway (137913); B Cell Receptor Signaling Pathway (198909); CXCR4-mediated Signaling Events Pathway (137910); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class I PI3K Signaling Events Pathway (138022); Cytokine Signaling In Immune System Pathway (366171); Disease Pathway (530764); EPHA Forward Signaling Pathway (138041); Ephrin B Reverse Signaling Pathway (138052)

ncbi summary :

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]

uniprot summary :

Hck: a protein-tyrosine kinase of the Src family that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms that have different subcellular localization. Protein type: Oncoprotein; Protein kinase, tyrosine (non-receptor); Kinase, protein; EC 2.7.10.2; Protein kinase, TK; TK group; Src family. Chromosomal Location of Human Ortholog: 20q11-q12. Cellular Component: Golgi apparatus; extrinsic to internal side of plasma membrane; transport vesicle; focal adhesion; cell projection; lysosome; actin filament; caveola; cytosol; nucleus. Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding. Biological Process: respiratory burst after phagocytosis; peptidyl-tyrosine phosphorylation; viral reproduction; protein amino acid autophosphorylation; regulation of phagocytosis; protein amino acid phosphorylation; regulation of cell shape; leukocyte migration during immune response; regulation of transcription factor activity; leukocyte degranulation; positive regulation of cell proliferation; lipopolysaccharide-mediated signaling pathway; mesoderm development; cell differentiation; cell adhesion; innate immune response-activating signal transduction; inflammatory response; integrin-mediated signaling pathway; cytokine and chemokine mediated signaling pathway; regulation of defense response to virus by virus; positive regulation of actin filament polymerization; regulation of inflammatory response; innate immune response; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage