catalog number :
MBS853533
products full name :
ATF5 Antibody
products short name :
ATF5
other names :
cyclic AMP-dependent transcription factor ATF-5; Cyclic AMP-dependent transcription factor ATF-5; cyclic AMP-dependent transcription factor ATF-5; transcription factor ATFx; cAMP-dependent transcription factor ATF-5; activating transcription factor 5; Activating transcription factor 5; Transcription factor ATFx
products gene name :
ATF5
other gene names :
ATF5; ATF5; ATFX; HMFN0395; ATFX; cAMP-dependent transcription factor ATF-5
uniprot entry name :
ATF5_HUMAN
reactivity :
Human, Mouse, Rat
form :
Lyophilized anti-ATF5 antibody purified by peptide affinity column containing 2% BSA and 0.02% NaNB3
concentration :
100ug/200ul
tested application :
Immunohistochemistry (IHC)
app notes :
Peptide ELISA titer: 1:20,000-1:80,000. Immunohistochemistry: 1:50-200. Optimal dilutions/concentrations should be determined by the end user.
other info1 :
Source Note: Rabbit polyclonal ATF5 (1) antibody was raised against a peptide at the C terminal residues of human ATF5 protein. Reactivity Note: Not yet tested in other species.
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
(1) Liu,W., Sun,M., Jiang,J., et al. Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity.Biochem. Biophys. Res. Commun. 321 (4), 954-960 (2004)
ncbi acc num :
NP_001180575.1
ncbi gb acc num :
NM_001193646.1
ncbi mol weight :
30,674 Da
ncbi pathways :
Myometrial Relaxation And Contraction Pathways (198759); Signaling Events Mediated By PRL Pathway (137969)
uniprot summary :
ATF-5: Transcriptional activator which binds the cAMP response element (CRE) (consensus: 5 -GTGACGT[AC][AG]-3 ), a sequence present in many viral and cellular promoters and blocks the differentiation of neuroprogenitor cells into neurons. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4. Belongs to the bZIP family. Protein type: DNA-binding. Chromosomal Location of Human Ortholog: 19q13.3. Cellular Component: nucleoplasm; transcription factor complex; cytoplasm. Molecular Function: protein binding; heat shock protein binding; transcription corepressor activity. Biological Process: circadian rhythm; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; olfactory bulb interneuron development; multicellular organism growth; negative regulation of astrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; post-embryonic development; negative regulation of apoptosis