antibody

WNT3A/WNT3

MBS8535221

0.1 mL

280 USD

polyclonal

goat

nonconjugated

human, mouse, rat

western blot, immunoprecipitation

Antibody

WNT3A/WNT3

[WNT3A/WNT3]

[Proto-oncogene Int-4 homolog, Int 4 antibody, INT4 antibody, MGC131950 antibody, MGC138321 antibody, MGC138323 antibody, Proto-oncogene Int-4 homolog antibody, Proto-oncogene Wnt-3 antibody, wingless type MMTV integration site family member 3 antibody, Wnt 3 proto oncogene protein antibody, WNT 3 proto oncogene protein precursor antibody, wnt3 antibody, WNT3_HUMAN antibody]

[proto-oncogene Wnt-3; Proto-oncogene Wnt-3; proto-oncogene Wnt-3; Wnt family member 3; Proto-oncogene Int-4 homolog]

[WNT3A/WNT3]

[WNT3]

[WNT3; WNT3; INT4; TETAMS; INT4]

Polyclonal

IgG

Goat

Human, Mouse, Rat

355

Immunogen affinity purified

Liquid; 1 *TBS (pH7.4), 1 %BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Store at +4 degree C

Western Blot (WB), Immunoprecipitation (IP)

WB: 1:100-1:1,000. IF: 1:50-1:500

Immunogen: Peptide. Conjugate: Non-conjugated

Subcellular location: Secreted

The Wnt gene family encodes secreted signaling molecules that bind to frizzled receptors and influence oncogenesis and developmental processes, including regulation of cell fate and patterning during embryogenesis. The Wnt family has two functional classes according to their biological activities; Wnts that signal through a Wnt-1/wingless pathway by stabilizing cytoplasmic ~-catenin, and Wnts that stimulate intracellular Ca2+ release and activate two kinases, CamK11 and PKC, in a G protein-dependent manner. Wnt-3 is present during development of the cerebellum and is restricted to the Purkinje cell layer in the adult. In motoneurons, Wnt-3 is a retrograde signal that controls terminal branching of muscle afferents. Human Wnt-3 is 98% homologous to mouse Wnt-3 protein and 84% homologous to human ,Wnt-3a protein. The human Wnt-3 gene clusters with the Wnt-15 gene at chromosome 17q21.31.

13540477

NP_110380.1

NM_030753.4

P56703

39 kDa

Basal Cell Carcinoma Pathway (83113); Basal Cell Carcinoma Pathway (525); Class B/2 (Secretin Family Receptors) Pathway (1269570); DNA Damage Response (only ATM Dependent) Pathway (198827); GPCR Ligand Binding Pathway (1269544); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); Hedgehog Signaling Pathway (83063); Hedgehog Signaling Pathway (474); Hippo Signaling Pathway (749777)

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (). Required for normal embryonic development, and especially for limb development (PubMed:14872406).

0.1 mL

280 USD