catalog number :
MBS853513
products full name :
ABCA1 Antibody
products short name :
ABCA1
other names :
Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 1 (ABCA1), mRNA; ATP-binding cassette sub-family A member 1; ATP-binding cassette sub-family A member 1; membrane-bound; ATP-binding cassette transporter A1; cholesterol efflux regulatory protein; ATP-binding cassette, sub-family A (ABC1), member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein
products gene name :
ABCA1
other gene names :
ABCA1; ABCA1; TGD; ABC1; CERP; ABC-1; HDLDT1; ABC1; CERP; ABC-1; ATP-binding cassette 1
uniprot entry name :
ABCA1_HUMAN
form :
Lyophilized ABCA1 antibody purified by protein A column containing 0.02% NaN3
concentration :
100ug/200ul
tested application :
Western Blot (WB)
app notes :
ELISA titer: 1:10,000-1:80,000. Western blot analysis: 1:1,000-1:2,000. Optimal dilutions/concentrations should be determined by the end user.
other info1 :
Source Note: Rabbit polyclonal ABCA1 (1) antibody was raised against a recombinate human ABCA1 protein 2085-2245aa (NM_005502). Reactivity Note: Predicted: Mouse, Rat; Not yet tested in other species.
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
(1) Iwamoto,N., Lu,R., Tanaka,N., et al. Calmodulin interacts with ATP binding cassette transporter A1 to protect from calpain-mediated degradation and upregulates high-density lipoprotein generation. Arterioscler. Thromb. Vasc. Biol. 30 (7), 1446-1452 (2010)
ncbi acc num :
NP_005493.2
ncbi gb acc num :
NM_005502
ncbi mol weight :
254,302 Da
ncbi pathways :
ABC Transporters Pathway 83035!!ABC Transporters Pathway 436!!Fat Digestion And Absorption Pathway 194385!!Fat Digestion And Absorption Pathway 194324!!Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway 160977!!Folate Metabolism Pathway 198833!!HDL-mediated Lipid Transport Pathway 106158!!Lipid Digestion, Mobilization, And Transport Pathway 106111!!Lipoprotein Metabolism Pathway 106156!!Metabolism Pathway 477135
ncbi summary :
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]