catalog number :
MBS8534989
products full name :
CLCA1
products short name :
[CLCA1]
products name syn :
[Calcium-activated chloride channel family member 1; hCLCA1; Calcium-activated chloride channel protein 1; CaCC-1; hCaCC-1]
other names :
[calcium-activated chloride channel regulator 1; Calcium-activated chloride channel regulator 1; calcium-activated chloride channel regulator 1; chloride channel accessory 1; Calcium-activated chloride channel family member 1; hCLCA1; Calcium-activated chloride channel protein 1; CaCC-1; hCaCC-1]
products gene name :
[CLCA1]
other gene names :
[CLCA1; CLCA1; CACC; GOB5; CACC1; CLCRG1; CaCC-1; hCLCA1; hCaCC-1; CACC1; hCLCA1; CaCC-1; hCaCC-1]
reactivity :
Human, Mouse, Rat
purity :
Immunogen affinity purified
form :
1*TBS (pH7.4), 1% BSA, 40% Glycerol.
storage stability :
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
tested application :
Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
other info1 :
Immunogen: Peptide. Preservative: 0.05% Sodium Azide.
ncbi acc num :
NP_001276.2
ncbi gb acc num :
NM_001285.3
ncbi pathways :
Alpha6-Beta4 Integrin Signaling Pathway (198807); Ion Channel Transport Pathway (187193); Olfactory Transduction Pathway (83087); Olfactory Transduction Pathway (498); Pancreatic Secretion Pathway (169306); Pancreatic Secretion Pathway (169295); Stimuli-sensing Channels Pathway (771568); Transmembrane Transport Of Small Molecules Pathway (106572)
ncbi summary :
This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq, Jul 2008]
uniprot summary :
May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.