antibody

TNF alpha

MBS8534675

0.1 mL

280 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, FACS, enzyme immunoassay

Antibody

TNF alpha

[TNF alpha]

[Tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2]

[tumor necrosis factor isoform 2; Tumor necrosis factor; tumor necrosis factor; tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a]

[TNF alpha]

[TNF-a]

[Tnf; Tnf; DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha; Tnfa; Tnfsf2; TNF-a; NTF; ICD1; ICD2]

Polyclonal

IgG

Rabbit

Mouse, Zebrafish

219

Immunogen affinity purified

1*TBS (pH7.4), 1% BSA, 40% Glycerol.

Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), ELISA (EIA)

Immunogen: Peptide. Preservative: 0.05% Sodium Azide.

518831589

NP_001265530.1

NM_001278601.1

P06804

AGE-RAGE Signaling Pathway In Diabetic Complications (1320037); AGE-RAGE Signaling Pathway In Diabetic Complications (1319775); Adipocytokine Signaling Pathway (83290); Adipocytokine Signaling Pathway (505); Adipogenesis Pathway (198299); African Trypanosomiasis Pathway (194387); African Trypanosomiasis Pathway (194323); Allograft Rejection Pathway (83316); Allograft Rejection Pathway (535); Alzheimer's Disease Pathway (83294)

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. Members of this family are classified based on primary sequence, function, and structure. This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological functions. It plays an important role in the innate immune response as well as regulating homeostasis but is also implicated in diseases of chronic inflammation. In mouse deficiency of this gene is associated with defects in response to bacterial infection, with defects in forming organized follicular dendritic cell networks and germinal centers, and with a lack of primary B cell follicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.

0.1 mL

280 USD