catalog number :
MBS853466
products full name :
TNFRSF17 Antibody
products short name :
TNFRSF17
other names :
Homo sapiens tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), mRNA; Tumor necrosis factor receptor superfamily member 17; tumor necrosis factor receptor superfamily member 17; B-cell maturation factor; B cell maturation antigen; B-cell maturation protein; tumor necrosis factor receptor superfamily, member 17; B-cell maturation protein; CD_antigen: CD269
products gene name :
TNFRSF17
other gene names :
TNFRSF17; TNFRSF17; BCM; BCMA; CD269; TNFRSF13A; BCM; BCMA
uniprot entry name :
TNR17_HUMAN
form :
Lyophilized TNFRSF17 Antibody serum containing 0.02% NaN3
tested application :
Western Blot (WB)
app notes :
Peptide ELISA titer: 1:10,000-1:40,000. Western blot analysis: 1:200-500. Optimal dilutions/concentrations should be determined by the end use
other info1 :
Source Note: Rabbit polyclonal TNFRSF17 (1) antibody was raised against a 15 amino acid peptide from near the intermediate residues of human TNFRSF17. Reactivity Note: Not yet tested in other species.
other info2 :
Pathway: tumor necrosis factor receptor superfamily, member 17
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
(1) Novak,A.J., Darce,J.R., Arendt,B.Ket,al Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival. Blood.2004;103(2) 689-694.
ncbi acc num :
NP_001183.2
ncbi gb acc num :
NM_001192
ncbi mol weight :
14,843 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Intestinal Immune Network For IgA Production Pathway (128760); Intestinal Immune Network For IgA Production Pathway (128670)
ncbi summary :
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
uniprot summary :
TNFRSF17: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2. Protein type: Receptor, misc.; Oncoprotein; Membrane protein, integral. Chromosomal Location of Human Ortholog: 16p13.1. Cellular Component: integral to membrane; plasma membrane; endomembrane system. Molecular Function: receptor activity. Biological Process: cell proliferation; immune system process; multicellular organismal development; signal transduction