antibody

ABCB8 Antibody

MBS853465

0.1 mg

290 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

ABCB8 Antibody

ABCB8

ATP-binding cassette sub-family B member 8, mitochondrial isoform b; ATP-binding cassette sub-family B member 8, mitochondrial; ATP-binding cassette sub-family B member 8, mitochondrial; mitochondrial ABC protein; mitochondrial ATP-binding cassette 1; ATP-binding cassette, sub-family B (MDR/TAP), member 8; Mitochondrial ATP-binding cassette 1; M-ABC1

ABCB8

ABCB8; ABCB8; MABC1; M-ABC1; EST328128; MABC1; M-ABC1

ABCB8_HUMAN

Polyclonal

Rabbit

Human

718

Lyophilized ABCB8 antibody purified by protein A column containing 0.02% NaN3

100ug/200ul

Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at -20 degree C after reconstitutionn. Avoid repeated freeze/defrost cycles.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

ELISA titer: 1:20,000-1:80,000. Western blot analysis: 1:500-1:1,000. Immunohistochemistry: 1:100-1:500. Optimal dilutions/concentrations should be determined by the end user.

Source Note: Rabbit polyclonal ABCB8 (1) antibody was raised against a recombinate human ABCB8 protein 450-687aa (BC141814). Reactivity Note: Predicted: Mouse, Rat; Not yet tested in other species.

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

156105685

NP_009119.2

NM_007188.4

59,383 Da

ABC Transporters Pathway (83035); ABC Transporters Pathway (436); ABC-family Proteins Mediated Transport Pathway (106573); Mitochondrial ABC Transporters Pathway (477113); Transmembrane Transport Of Small Molecules Pathway (106572)

This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

ABCB8: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes. [provided by RefSeq, Jul 2008]. Protein type: Mitochondrial; Membrane protein, multi-pass; Hydrolase; Membrane protein, integral; Transporter; Transporter, ABC family. Chromosomal Location of Human Ortholog: 7q36. Cellular Component: mitochondrial envelope; mitochondrion; membrane; mitochondrial inner membrane; nucleolus; integral to membrane; ATP-binding cassette (ABC) transporter complex; nucleus. Molecular Function: transporter activity; ATPase activity, coupled to transmembrane movement of substances; ATP binding. Biological Process: metabolic process; transport; transmembrane transport

0.1 mg

290 USD