catalog number :
MBS853455
products full name :
Period Circadian Protein 2 (Phospho-Ser662) Antibody
products short name :
Period Circadian Protein 2
products name syn :
hPER2; KIAA0347; Period circadian protein 2
other names :
period circadian protein homolog 2; Period circadian protein homolog 2; period circadian protein homolog 2; hPER2; period 2; period homolog 2; period circadian protein 2; circadian clock protein PERIOD 2; period circadian clock 2; Circadian clock protein PERIOD 2
other gene names :
PER2; PER2; FASPS; FASPS1; KIAA0347; hPER2
uniprot entry name :
PER2_HUMAN
reactivity :
Human, Mouse
specificity :
Period Circadian Protein 2 (Phospho-Ser662) antibody detects endogenous levels of Period Circadian Protein 2 only when phosphorylated at serine 662.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation s
form :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20 degree C for 1 year
tested application :
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
app notes :
WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:5000
other info1 :
Reactivity Note: Human (Identities = 100%, Positives = 100%); Mouse (Identities = 90%, Positives = 90%)
other info2 :
Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human Period Circadian Protein 2 around the phosphorylation site of serine 662 (A-E-SP-V-A). All Sites: Human: Ser662; Mouse: Ser659. Pathway: Phospho-specific
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
Ikeda M., Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases. Camacho F., FEBS Lett. 489:159-165(2001). Nagase T., DNA Res. 4:141-150(1997).
ncbi acc num :
NP_073728.1
ncbi gb acc num :
NM_022817.2
ncbi mol weight :
45,175 Da
ncbi pathways :
BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway 477138!!Circadian Clock Pathway 187173!!Circadian Entrainment Pathway 698773!!Circadian Entrainment Pathway 699872!!Circadian Rhythm Pathway 83084!!Circadian Rhythm Pathway 495!!Diurnally Regulated Genes With Circadian Orthologs Pathway 198813!!Herpes Simplex Infection Pathway 377873!!Herpes Simplex Infection Pathway 377865!!Transcriptional Misregulation In Cancer Pathway 523016
ncbi summary :
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]