Retinoic Acid Receptor beta Antibody | MyBioSource MBS853439 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Retinoic Acid Receptor beta Antibody

catalog :

MBS853439

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS853439

products type :

Antibody

products full name :

Retinoic Acid Receptor beta Antibody

products short name :

Retinoic Acid Receptor beta

products name syn :

Retinoic Acid Receptor b Antibody

other names :

retinoic acid receptor beta isoform 1; Retinoic acid receptor beta; retinoic acid receptor beta; RAR-beta; RAR-epsilon; HBV-activated protein; hepatitis B virus activated protein; retinoic acid receptor, beta polypeptide; nuclear receptor subfamily 1 group B member 2; retinoic acid receptor, beta; HBV-activated protein; Nuclear receptor subfamily 1 group B member 2; RAR-epsilon

other gene names :

RARB; RARB; HAP; RRB2; NR1B2; MCOPS12; HAP; NR1B2; RAR-beta

uniprot entry name :

RARB_HUMAN

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

448

specificity :

Retinoic Acid Receptor beta antibody detects endogenous levels of total Retinoic Acid Receptor beta protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

100ug/100ul

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:20000

other info2 :

Immunogen: The antiserum was produced against synthesized peptide derived from human Retinoic Acid Receptor beta. Pathway: Receptors

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Reuben Lotan, N. Engl. J. Med., May 1995; 332: 1405 - 1411. Andrew Yen, Mol. Pharmacol., Dec 2004; 66: 1727 - 1737. K Swisshelm, Cell Growth Differ., Feb 1994; 5: 133. F Aoudjit, Cell Growth Differ., May 1995; 6: 515.

ncbi gi num :

14916494

ncbi acc num :

NP_000956.2

ncbi gb acc num :

NM_000965.4

uniprot acc num :

P10826

ncbi mol weight :

ncbi pathways :

Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Integrated Pancreatic Cancer Pathway (711360); Non-small Cell Lung Cancer Pathway (83119); Non-small Cell Lung Cancer Pathway (531); Nuclear Receptor Transcription Pathway (105979); Nuclear Receptors Pathway (198848); Nuclear Receptors In Lipid Metabolism And Toxicity Pathway (198887); Pathways In Cancer (83105); Small Cell Lung Cancer Pathway (83118)

ncbi summary :

This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]

uniprot summary :

RARB: is a receptor for retinoic acid, a potent mammalian morphogen and teratogen that has profound effects on vertebrate development. RARB is a member of the nuclear receptor superfamily. Controls cell function by directly regulating gene expression. Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain. Four splice-variant isoforms have been described. Isoform beta-1 and beta-2 are nuclear and isoform beta-4 cytoplasmic. Protein type: Motility/polarity/chemotaxis; Nuclear receptor; Oncoprotein. Chromosomal Location of Human Ortholog: 3p24.2. Cellular Component: nucleoplasm; cytoplasm; nucleus. Molecular Function: retinoid X receptor binding; protein binding; DNA binding; zinc ion binding; protein complex binding; steroid hormone receptor activity; drug binding; retinoic acid receptor activity. Biological Process: retinoic acid receptor signaling pathway; transcription initiation from RNA polymerase II promoter; regulation of myelination; glandular epithelial cell development; striatum development; positive regulation of apoptosis; embryonic eye morphogenesis; multicellular organism growth; negative regulation of chondrocyte differentiation; ventricular cardiac muscle cell differentiation; negative regulation of transcription from RNA polymerase II promoter; signal transduction; embryonic hindlimb morphogenesis; negative regulation of cell proliferation; ureteric bud development; positive regulation of cell proliferation; steroid hormone mediated signaling; gene expression; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation; embryonic gut development; transmembrane transport; negative regulation of apoptosis. Disease: Microphthalmia, Syndromic 12

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage