SGOL1 Antibody | MyBioSource MBS853417 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

SGOL1 Antibody

catalog :

MBS853417

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS853417

products type :

Antibody

products full name :

SGOL1 Antibody

products short name :

SGOL1

products name syn :

Shugoshin-like 1; hSgo1; Serologically defined breast cancer antigen NY-BR-85; SGO1

other names :

shugoshin-like 1 isoform A1; Shugoshin-like 1; shugoshin-like 1; hSgo1; shugoshin 1AB protein; shugoshin 1CD protein; shugoshin 1EF protein; shugoshin 1GH protein; shugoshin 1KL protein; serologically defined breast cancer antigen NY-BR-85; shugoshin-like 1 (S. pombe); Serologically defined breast cancer antigen NY-BR-85

products gene name :

SGOL1

other gene names :

SGOL1; SGOL1; SGO; Sgo1; NY-BR-85; SGO1; hSgo1

uniprot entry name :

SGOL1_HUMAN

host :

Rabbit

reactivity :

Human

sequence length :

527

specificity :

SGOL1 antibody detects endogenous levels of total SGOL1 protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB: 1:500~1:1000, ELISA: 1:20000

other info2 :

Immunogen: The antiserum was produced against synthesized peptide derived from internal of human SGOL1. Pathway: Cell Cycle

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

McGuinness B.E., PLoS Biol. 3:433-449(2005). Kitajima T.S., Curr. Biol. 15:353-359(2005). Tang Z., Proc. Natl. Acad. Sci. U.S.A. 101:18012-18017(2004). ------------------------------------------------------------------------------------------------------------------------------------------

ncbi gi num :

60302875

ncbi acc num :

NP_001012409.1

ncbi gb acc num :

NM_001012409.2

uniprot acc num :

Q5FBB7

ncbi mol weight :

24,646 Da

ncbi pathways :

Aurora B Signaling Pathway (138080); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); M Phase Pathway (105812); Mitotic Anaphase Pathway (105818); Mitotic Metaphase And Anaphase Pathway (730317); Mitotic Prometaphase Pathway (105815); Oocyte Meiosis Pathway (126909); Oocyte Meiosis Pathway (126872); PLK1 Signaling Events Pathway (138007)

ncbi summary :

The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

uniprot summary :

SGO1: Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Belongs to the shugoshin family. 7 isoforms of the human protein are produced by alternative splicing. Protein type: Cell cycle regulation. Chromosomal Location of Human Ortholog: 3p24.3. Cellular Component: kinetochore; nucleoplasm; spindle pole; centrosome; cytoplasm; cytosol; chromosome, pericentric region; condensed nuclear chromosome, pericentric region. Molecular Function: protein binding; kinase binding. Biological Process: mitosis; cell division; mitotic cell cycle; attachment of spindle microtubules to kinetochore; meiotic chromosome segregation; centriole-centriole cohesion; chromosome segregation. Disease: Chronic Atrial And Intestinal Dysrhythmia

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage