antibody

CHP Antibody

MBS853393

0.1 mg

215 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, enzyme immunoassay

Antibody

CHP Antibody

CHP

Calcineurin B homolog; Calcineurin homologous protein; calcium binding protein P22; Calcium-binding protein CHP; Calcium-binding protein p22; CHP; CHP1; SLC9A1 binding protein; SLC9A1BP

calcineurin B homologous protein 1; Calcineurin B homologous protein 1; calcineurin B homologous protein 1; SLC9A1 binding protein; calcineurin B-like protein; calcium binding protein P22; calcium-binding protein CHP; calcium-binding protein p22; calcineurin homologous protein; calcineurin-like EF hand protein 1; EF-hand calcium-binding domain-containing protein p22; calcineurin-like EF-hand protein 1; Calcineurin B-like protein; Calcium-binding protein CHP; Calcium-binding protein p22; EF-hand calcium-binding domain-containing protein p22

CHP

CHP1; CHP1; CHP; p22; p24; Sid470p; SLC9A1BP; CHP

CHP1_HUMAN

Rabbit

Human, Mouse, Rat

195

CHP antibody detects endogenous levels of total CHP protein.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at -20 degree C for 1 year

Western Blot (WB), ELISA (EIA)

WB: 1:500~1:1000, ELISA: 1:20000

Immunogen: The antiserum was produced against synthesized peptide derived from N-terminal of human CHP. Pathway: Intermediates

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

Lin X., Proc. Natl. Acad. Sci. U.S.A. 93:12631-12636(1996). Ebert L., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. Ota T., Nat. Genet. 36:40-45(2004).

6005731

NP_009167.1

NM_007236.4

Q99653

22,456 Da

Alzheimers Disease Pathway (672448); Calcium Signaling In The CD4+ TCR Pathway (137941); Disease Pathway (530764); Glycogen Storage Diseases Pathway (980468); Glycosaminoglycan Metabolism Pathway (645297); Hyaluronan Metabolism Pathway (645298); Hyaluronan Uptake And Degradation Pathway (645300); MPS I - Hurler Syndrome Pathway (685537); MPS II - Hunter Syndrome Pathway (685538); MPS IIIA - Sanfilippo Syndrome A Pathway (685539)

This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008]

CHP: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate- phosphorylations in a calcium-dependent manner. Belongs to the calcineurin regulatory subunit family. CHP subfamily. Protein type: Calcium-binding. Chromosomal Location of Human Ortholog: 15q13.3. Cellular Component: microtubule cytoskeleton; Golgi membrane; transport vesicle; focal adhesion; endoplasmic reticulum; cytoplasm; ER-Golgi intermediate compartment; plasma membrane; cytosol; nucleus. Molecular Function: protein binding; potassium channel regulator activity; protein kinase inhibitor activity; transporter activity; microtubule binding; calcium ion binding; kinase binding; calcium-dependent protein binding. Biological Process: protein stabilization; glycosaminoglycan metabolic process; negative regulation of protein import into nucleus; pathogenesis; transcytosis; protein oligomerization; cytoplasmic microtubule organization and biogenesis; calcium ion-dependent exocytosis; hyaluronan catabolic process; positive regulation of protein transport; negative regulation of protein amino acid phosphorylation; positive regulation of protein amino acid glycosylation; inhibition of NF-kappaB transcription factor; small GTPase mediated signal transduction; carbohydrate metabolic process; regulation of intracellular pH; negative regulation of protein kinase activity; negative regulation of protein ubiquitination; negative regulation of protein amino acid autophosphorylation; protein export from nucleus; positive regulation of sodium:hydrogen antiporter activity; membrane docking; hyaluronan metabolic process; potassium ion transport; microtubule bundle formation

0.1 mg

215 USD