catalog number :
MBS853365
products full name :
Neurogenin 2 Antibody
products short name :
Neurogenin 2
other names :
neurogenin-2; Neurogenin-2; neurogenin-2; protein atonal homolog 4; class A basic helix-loop-helix protein 8; neurogenin 2; Class A basic helix-loop-helix protein 8; bHLHa8; Protein atonal homolog 4
other gene names :
NEUROG2; NEUROG2; NGN2; Atoh4; ngn-2; Math4A; bHLHa8; ATOH4; BHLHA8; NGN2; NGN-2; bHLHa8
uniprot entry name :
NGN2_HUMAN
reactivity :
Human, Mouse, Rat
form :
Lyophilized anti- neurogenin 2 antibody purified by peptide affinitycolumn containing 0.5% BSA and0.02% NaN3
concentration :
100ug/200ul
storage stability :
Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at -20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Peptide ELISA titer: 1:80,000. Western blot analysis: 1:200-1,000. Immunohistochemistry: 1:50-200. Optimal dilutions/concentrations should be determined by the end user.
other info1 :
Source Note: Rabbit polyclonal Neurogenin 2 (1) antibody was raised against a 16 amino acid peptide from near the N terminal residues of human Neurogenin 2 protein. Reactivity Note: Not yet tested in other species.
other info2 :
Pathway: Neurogenin 2
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
ncbi gb acc num :
NM_024019.3
ncbi mol weight :
28,621 Da
ncbi summary :
This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons. [provided by RefSeq, Apr 2012]
uniprot summary :
neurogenin 2: Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5 -CANNTG-3 ). Protein type: Transcription factor. Chromosomal Location of Human Ortholog: 4q25. Cellular Component: nucleus. Molecular Function: protein dimerization activity; sequence-specific DNA binding. Biological Process: axon guidance; cell fate commitment; transcription, DNA-dependent; cell maturation; forebrain development; neuron migration; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation; central nervous system neuron development