antibody

RPS3 Antibody

MBS853340

0.1 mg

215 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

RPS3 Antibody

RPS3

40S ribosomal protein S3; RS3

40S ribosomal protein S3 isoform 1; 40S ribosomal protein S3; 40S ribosomal protein S3; IMR-90 ribosomal protein S3; ribosomal protein S3

RPS3

RPS3; RPS3; S3

RS3_HUMAN

Rabbit

Human, Mouse, Rat

243

RPS3 antibody detects endogenous levels of total RPS3 protein.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at -20 degree C for 1 year

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:40000

Reactivity Note: Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)

Immunogen: The antiserum was produced against synthesized peptide derived from internal of human RPS3. Pathway: Intermediates

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

Yoshihama M., Genome Res. 12:379-390(2002). Nousiainen M., Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Molina H., Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). ------------------------------------------------------------------------------------------------------------------------------------------

15718687

NP_000996.2

NM_001005.4

P23396

28,487 Da

Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway (105970); Cap-dependent Translation Initiation Pathway (105967); Cytoplasmic Ribosomal Proteins Pathway (198853); Disease Pathway (530764); Eukaryotic Translation Elongation Pathway (105976); Eukaryotic Translation Initiation Pathway (105966); Eukaryotic Translation Termination Pathway (105978); Formation Of A Pool Of Free 40S Subunits Pathway (105968); Formation Of The Ternary Complex, And Subsequently, The 43S Complex Pathway (105969); GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway (105973)

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

RPS3: a component of the 40S ribosomal subunit of eukaryotes. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Overexpressed in colorectal cancer. Protein type: Translation; Apoptosis; RNA-binding; Ribosomal; EC 4.2.99.18. Chromosomal Location of Human Ortholog: 11q13.3-q13.5. Cellular Component: focal adhesion; membrane; cytoplasm; mitochondrial inner membrane; nucleolus; spindle; ribonucleoprotein complex; nucleus; cytosol. Molecular Function: mRNA binding; NF-kappaB binding; protein binding; enzyme binding; DNA-(apurinic or apyrimidinic site) lyase activity; structural constituent of ribosome; oxidized purine base lesion DNA N-glycosylase activity; protein kinase A binding; iron-sulfur cluster binding; damaged DNA binding; protein kinase binding. Biological Process: mitosis; SRP-dependent cotranslational protein targeting to membrane; transcription, DNA-dependent; viral reproduction; translation; apoptosis; translational termination; viral infectious cycle; DNA repair; DNA catabolic process, endonucleolytic; activation of NF-kappaB transcription factor; regulation of translation; translational elongation; cellular protein metabolic process; cell division; translational initiation; mRNA catabolic process, nonsense-mediated decay; gene expression; viral transcription; response to DNA damage stimulus; negative regulation of DNA repair

0.1 mg

215 USD