catalog number :
MBS853325
products full name :
PLCB2 Antibody
products short name :
PLCB2
products name syn :
1-phosphatidylinositol-4; 5-bisphosphate phosphodiesterase beta-2; FLJ38135; Phosphoinositide phospholipase C-beta-2; phospholipase C; beta 2; Phospholipase C-beta-2; PLC-beta-2; PLCB2
other names :
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; phosphoinositide phospholipase C-beta-2; phospholipase C, beta 2; Phosphoinositide phospholipase C-beta-2; Phospholipase C-beta-2; PLC-beta-2
products gene name :
PLCB2
other gene names :
PLCB2; PLCB2; PLC-beta-2; PLC-beta-2
uniprot entry name :
PLCB2_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
PLCB2 antibody detects endogenous levels of total PLCB2 protein.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20 degree C for 1 year
tested application :
Western Blot (WB), ELISA (EIA)
app notes :
WB: 1:500~1:1000, ELISA: 1:5000
other info2 :
Immunogen: The antiserum was produced against synthesized peptide derived from C-terminal of human PLCB2. Pathway: Intermediates
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
Park D., J. Biol. Chem. 267:16048-16055(1992). Ota T., Nat. Genet. 36:40-45(2004). Zody M.C., Nature 440:671-675(2006).
ncbi acc num :
NP_001271226.1
ncbi gb acc num :
NM_001284297.1
ncbi mol weight :
132,511 Da
ncbi pathways :
Acetylcholine Regulates Insulin Secretion Pathway (105924); Activation Of Kainate Receptors Upon Glutamate Binding Pathway (161043); Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Alpha-synuclein Signaling Pathway (137913); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448)
uniprot summary :
PLCB2: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.1.4.11; Phospholipase; Carbohydrate Metabolism - inositol phosphate. Chromosomal Location of Human Ortholog: 15q15. Cellular Component: cytosol. Molecular Function: signal transducer activity; calcium ion binding; phosphoinositide phospholipase C activity; phospholipase C activity. Biological Process: synaptic transmission; inositol phosphate metabolic process; phospholipase C activation; metabolic process; phospholipid metabolic process; sensory perception of bitter taste; lipid catabolic process