mGluR7 Antibody | MyBioSource MBS853322 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

mGluR7 Antibody

catalog :

MBS853322

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS853322

products type :

Antibody

products full name :

mGluR7 Antibody

products short name :

mGluR7

products name syn :

EAA5; GLR7; GluR7a; dJ1090M5.1 (glutamate receptor; ionotropic; kainate 3 (GLUR7)); excitatory amino acid receptor 5; glutamate receptor 7 precursor

other names :

metabotropic glutamate receptor 7 isoform a; Metabotropic glutamate receptor 7; metabotropic glutamate receptor 7; protein phosphatase 1, regulatory subunit 87; glutamate receptor, metabotropic 7

products gene name :

mGluR7

other gene names :

GRM7; GRM7; GLUR7; MGLU7; GPRC1G; MGLUR7; PPP1R87; GPRC1G; MGLUR7; mGluR7

uniprot entry name :

GRM7_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

915

specificity :

GluR7 antibody detects endogenous levels of total GluR7 protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

100ug/100ul

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:20000

other info2 :

Immunogen: The antiserum was produced against synthesized peptide derived from human GluR7. Pathway: Channel

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Hans H. Schiffer, J. Neurosci., Dec 2000; 20: 9025. Nathalie Strutz, J. Neurosci., Jan 2001; 21: 401. Fr©d©ric Jaskolski, J. Biol. Chem., Jun 2005; 280: 22968 - 22976. DE Hamassaki-Britto, J. Neurosci., May 1993; 13: 1888.

ncbi gi num :

4504147

ncbi acc num :

NP_000835.1

ncbi gb acc num :

NM_000844.3

uniprot acc num :

Q14831

ncbi mol weight :

101,302 Da

ncbi pathways :

Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway (106381); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway (198839); Glutamatergic Synapse Pathway (213818); Glutamatergic Synapse Pathway (213811); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Signal Transduction Pathway (477114)

ncbi summary :

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

uniprot summary :

mGluR7: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 3. Chromosomal Location of Human Ortholog: 3p26.1-p25.1. Cellular Component: asymmetric synapse; presynaptic membrane; postsynaptic membrane; axon; integral to plasma membrane; dendrite; integral to membrane; presynaptic active zone; plasma membrane; dendritic shaft; cell cortex; receptor complex. Molecular Function: voltage-gated calcium channel activity; group III metabotropic glutamate receptor activity; glutamate binding; calcium channel regulator activity; calcium ion binding; glutamate receptor activity; PDZ domain binding. Biological Process: behavioral fear response; regulation of synaptic transmission, glutamatergic; negative regulation of glutamate secretion; short-term memory; sensory perception of smell; negative regulation of adenylate cyclase activity; regulation of cyclase activity; transmission of nerve impulse; synaptic transmission; negative regulation of cAMP biosynthetic process; sensory perception of sound; adult behavior; conditioned taste aversion; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage