catalog number :
MBS8533171
products full name :
Anti-beta2-microglobulin Mouse mAb
products short name :
[beta2-microglobulin]
products name syn :
[B2MG_HUMAN; Beta2microglobin; Beta2microglobulin; Beta2microglobulinprecursor; Betachainofmhcclass1proteins; BetachainofMHCclassImolecules; Beta-2-microglobulinformpI5.3; CDABP0092; Hdcma22p.]
other names :
[beta-2-microglobulin; Beta-2-microglobulin; beta-2-microglobulin; beta-2-microglobulin]
products gene name :
[B2M]
other gene names :
[B2M; B2M; IMD43]
purity :
Affinity purified
form :
Purified mouse monoclonal antibjody in PBS (pH 7.4) containing 0.03% Proclin300.
storage stability :
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
tested application :
ELISA (EIA)
other info1 :
Immunogen: Purified recombinant human beta2-microglobulin protein expressed in E Coli.
products description :
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
ncbi acc num :
NP_004039.1
ncbi gb acc num :
NM_004048
ncbi pathways :
Adaptive Immune System Pathway (366160); Amyloids Pathway (366238); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (366163); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Antigen Processing-Cross Presentation Pathway (477122); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Cytokine Signaling In Immune System Pathway (366171); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550)
ncbi summary :
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]
uniprot summary :
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).