catalog number :
MBS8532923
products full name :
PCSK9/Proprotein Convertase 9
products short name :
[PCSK9/Proprotein Convertase 9]
products name syn :
[Proprotein Convertase Subtilisin/Kexin Type 9; Neural Apoptosis-Regulated Convertase 1; NARC-1; Proprotein Convertase 9; PC9; Subtilisin/Kexin-Like Protease PC9; PCSK9; NARC1]
products gene name :
[PCSK9]
purity :
Greater than 95% as determined by reducing SDS-PAGE.
form :
Supplied as a 0.2 um filtered solution of 50mM HEPES,150mM NaCl, 20%Glycerol, pH 7.4
storage stability :
Store at <-20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
other info1 :
Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test. Species: Human. Product State: Liquid
products description :
Description: Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9 is produced by our Mammalian expression system and the target gene encoding Gln31-Gln152&Ser153-Gln692 is expressed with a 6His tag at the C-terminus. Background: Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER, the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.