catalog number :
MBS853279
products full name :
Plexin B1 Antibody
products short name :
Plexin B1
other names :
Homo sapiens plexin B1 (PLXNB1), transcript variant 1, mRNA; Plexin-B1; plexin-B1; plexin 5; semaphorin receptor SEP; plexin B1; Semaphorin receptor SEP
other gene names :
PLXNB1; PLXNB1; SEP; PLXN5; PLEXIN-B1; KIAA0407; PLXN5; SEP
uniprot entry name :
PLXB1_HUMAN
reactivity :
Human, Mouse, Rat
form :
Lyophilized rabbit anti-Plexin-B1 purified by protein A column containing 0.02% NaN3
concentration :
100ug/200ul
storage stability :
Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at -20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Peptide ELISA titer: 1:10,000-1:40,000. Western blot analysis: 1:200-1,000. Immunohistochemistry: 1:50-200. Optimal dilutions/concentrations should be determined by the end user.
other info1 :
Source Note: Rabbit polyclonal Plexin- B1 (1) antibody was raised against a 14 amino acid peptide from near the N terminal residues of human Plexin- B1 protein. Reactivity Note: Not yet tested in other species.
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
ncbi acc num :
NP_002664.2
ncbi gb acc num :
NM_002673
ncbi mol weight :
78,395 Da
ncbi pathways :
Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); G Alpha (12/13) Signalling Events Pathway (106041); GPCR Downstream Signaling Pathway (119548); Sema4D In Semaphorin Signaling Pathway (119520); Sema4D Induced Cell Migration And Growth-cone Collapse Pathway (119522); Sema4D Mediated Inhibition Of Cell Attachment And Migration Pathway (119521); Semaphorin Interactions Pathway (119519)
uniprot summary :
PLXNB1: Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Belongs to the plexin family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 3p21.31. Cellular Component: integral to plasma membrane; plasma membrane; extracellular region; intracellular. Molecular Function: protein binding; transmembrane receptor activity; semaphorin receptor activity; GTPase activating protein binding; receptor activity; semaphorin receptor binding. Biological Process: positive regulation of phosphoinositide 3-kinase cascade; regulation of cell shape; axon guidance; cell migration; positive regulation of axonogenesis; negative regulation of osteoblast proliferation; negative regulation of cell adhesion; signal transduction; neurite morphogenesis; regulation of cytoskeleton organization and biogenesis