Collagen IV alpha 2 Antibody | MyBioSource MBS853194 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Collagen IV alpha 2 Antibody

catalog :

MBS853194

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS853194

products type :

Antibody

products full name :

Collagen IV alpha 2 Antibody

products short name :

Collagen IV alpha 2

products name syn :

Collagen IV a2 Antibody; CO4A2; Collagen alpha-2(IV) chain; alpha 2 type IV collagen; canstatin; collagen type IV alpha 2

other names :

collagen alpha-2(IV) chain preproprotein; Collagen alpha-2(IV) chain; collagen alpha-2(IV) chain; collagen alpha-2(IV) chain; canstatin; collagen, type IV, alpha 2

other gene names :

COL4A2; COL4A2; ICH; POREN2

uniprot entry name :

CO4A2_HUMAN

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

1712

specificity :

Collagen IV alpha2 antibody detects endogenous levels of total Collagen IV alpha2 protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

1mg/ml

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100, IF: 1:100~1:500, ELISA: 1:20000

other info2 :

Immunogen: The antiserum was produced against synthesized peptide derived from internal of human Collagen IV alpha2. Pathway: Adhesion

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Dunham A., Nature 428:522-528(2004). Fischer G., Biochem. J. 292:687-695(1993). Kamphaus G.D., J. Biol. Chem. 275:1209-1215(2000). ------------------------------------------------------------------------------------------------------------------------------------------

ncbi gi num :

116256354

ncbi acc num :

NP_001837.2

ncbi gb acc num :

NM_001846.2

uniprot acc num :

P08572

ncbi mol weight :

167,553 Da

ncbi pathways :

Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Axon Guidance Pathway (105688); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Collagen Biosynthesis And Modifying Enzymes Pathway (645289); Collagen Formation Pathway (645288); Developmental Biology Pathway (477129); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479)

ncbi summary :

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008]

uniprot summary :

COL4A2: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a chicken-wire meshwork together with laminins, proteoglycans and entactin/nidogen. Defects in COL4A2 are the cause of porencephaly type 2 (POREN2). POREN2 is a neurologic disorder characterized by a fluid-filled cysts or cavities within the cerebral hemispheres. Affected individuals typically have hemiplegia, seizures, and intellectual disability. Porencephaly type 2, or schizencephalic porencephaly, is usually symmetric and represents a primary defect in the development of the cerebral ventricles. Defects in COL4A2 are a cause of susceptibility to intracerebral hemorrhage (ICH). ICH is a pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke. Belongs to the type IV collagen family. Protein type: Extracellular matrix; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 13q34. Cellular Component: extracellular matrix; intracellular membrane-bound organelle; endoplasmic reticulum lumen; collagen type IV; extracellular region. Molecular Function: protein binding; extracellular matrix structural constituent. Biological Process: receptor-mediated endocytosis; axon guidance; collagen catabolic process; extracellular matrix disassembly; negative regulation of angiogenesis; extracellular matrix organization and biogenesis; transcription, DNA-dependent; angiogenesis. Disease: Porencephaly 2; Hemorrhage, Intracerebral, Susceptibility To

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage