catalog number :
MBS8531841
products full name :
OREX Polyclonal Antibody
products short name :
[OREX]
products name syn :
[Orexin; Hypocretin; Hcrt; Orexin-A; Hypocretin-1; Hcrt1; Orexin-B; Hypocretin-2; Hcrt2; HCRT; OX; PPORX; PPOX]
other names :
[orexin; Orexin; orexin; hypocretin neuropeptide precursor; Hypocretin; Hcrt]
products gene name :
[OREX]
other gene names :
[HCRT; HCRT; OX; PPOX; NRCLP1; OX; PPORX; PPOX; Hcrt; Hcrt1; Hcrt2]
reactivity :
Human, Mouse, Rat
purity :
The antibody was affinity purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
storage stability :
Store at -20°C for 1 year.
tested application :
Western Blot (WB), ELISA (EIA)
app notes :
WB: 1:500-2000. ELISA: 1:5000-20000
other info1 :
Immunogen: Synthesized peptide derived from human protein. at AA range: 21-70
other info2 :
Antibody Type: Orexin (Hypocretin)(Hcrt)[Cleaved into: Orexin-A (Hypocretin-1)(Hcrt1); Orexin-B (Hypocretin-2)(Hcrt2)}
ncbi acc num :
NP_001515.1
ncbi gb acc num :
NM_001524.1
ncbi pathways :
Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); Orexin And Neuropeptides FF And QRFP Bind To Their Respective Receptors Pathway (106362); Peptide Ligand-binding Receptors Pathway (106358); Signal Transduction Pathway (477114); Signaling By GPCR Pathway (106356)
ncbi summary :
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]
uniprot summary :
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.