PLD1 (Phospho-Thr147) Antibody | MyBioSource MBS853109 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PLD1 (Phospho-Thr147) Antibody

catalog :

MBS853109

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS853109

products type :

Antibody

products full name :

PLD1 (Phospho-Thr147) Antibody

products short name :

PLD1

products name syn :

Phospholipase D1; PLD 1; hPLD1; EC=3.1.4.4; Choline phosphatase 1; Phosphatidylcholine-hydrolyzing phospholipase D1

other names :

phospholipase D1 isoform a; Phospholipase D1; phospholipase D1; choline phosphatase 1; phosphatidylcholine-hydrolyzing phospholipase D1; phospholipase D1, phosphatidylcholine-specific; Choline phosphatase 1; Phosphatidylcholine-hydrolyzing phospholipase D1

products gene name :

PLD1

other gene names :

PLD1; PLD1; PLD 1; hPLD1

uniprot entry name :

PLD1_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1074

specificity :

PLD1 (Phospho-Thr147) antibody detects endogenous levels of PLD1 only when phosphorylated at threonine 147.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation s

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

1mg/ml

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

WB: 1:500~1:1000, ELISA: 1:40000

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human PLD1 around the phosphorylation site of threonine 147. All Sites: Human: Thr147; Mouse: Thr147; Rat: Thr147. Pathway: Phospho-specific

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Hammond S.M., J. Biol. Chem. 272:3860-3868(1997) [PubMed: 9013646]. Steed P.M., FASEB J. 12:1309-1317(1998) [PubMed: 9761774]. Lopez I., J. Biol. Chem. 273:12846-12852(1998) [PubMed: 9582313].

ncbi gi num :

4505873

ncbi acc num :

NP_002653.1

ncbi gb acc num :

NM_002662.4

uniprot acc num :

Q13393

ncbi mol weight :

112,184 Da

ncbi pathways :

Alpha-synuclein Signaling Pathway (137913); Arf6 Downstream Pathway (138038); Arf6 Trafficking Events Pathway (137954); CDC42 Signaling Events Pathway (137994); EGFR1 Signaling Pathway (198782); Endocytosis Pathway (102279); Endocytosis Pathway (102181); ErbB1 Downstream Signaling Pathway (138057); Ether Lipid Metabolism Pathway (82990); Ether Lipid Metabolism Pathway (365)

ncbi summary :

This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011]

uniprot summary :

PLD1: a phosphatidylcholine-hydrolyzing phospholipase. Activated by ADP-ribosylated Rho and protein kinase C. Implicated as a critical step in numerous cellular pathways including membrane trafficking and the regulation polymorphonuclear leukocyte degranulation and oxidant production. May be involved in the regulation of perinuclear intravesicular membrane traffic. Four splice-variant isoforms have been described. Protein type: Lipid Metabolism - glycerophospholipid; Phospholipase; EC 3.1.4.4; Motility/polarity/chemotaxis; Lipid Metabolism - ether lipid. Chromosomal Location of Human Ortholog: 3q26. Cellular Component: Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; membrane; lysosomal membrane; late endosome membrane; endocytic vesicle; perinuclear region of cytoplasm; apical plasma membrane; endosome. Molecular Function: protein binding; phospholipase D activity; phosphoinositide binding. Biological Process: defense response to Gram-positive bacterium; phosphatidylglycerol biosynthetic process; phospholipid metabolic process; small GTPase mediated signal transduction; glycerophospholipid biosynthetic process; Ras protein signal transduction; phosphatidic acid biosynthetic process; chemotaxis; lipid catabolic process; regulation of microvillus biogenesis

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage