product summary
Loading...
company name :
MyBioSource
product type :
antibody
product name :
SREBP-1c Antibody
catalog :
MBS8529268
quantity :
0.1 mg
price :
280 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot
more info or order :
image
image 1 :
Western Blot analysis of HeLa, HepG2 cells using SREBP-1 Polyclonal Antibody. Secondary antibody ?catalog MBS8529268) was diluted at 1:20000
image 2 :
Western Blot analysis of various cells using Antibody diluted at 1:1000. Secondary antibody?catalog MBS8529268) was diluted at 1:20000
image 3 :
Western Blot analysis of 1,mouse-liver 2,hela 3,mouse-brain cells using primary antibody diluted at 1:1000 ?catalog MBS8529268)(4°C overnight). Secondary antibody?Goat Anti-rabbit IgG IRDye 800( diluted at 1:5000, 25°C, 1 hour)
product information
catalog number :
MBS8529268
products type :
Antibody
products full name :
SREBP-1c Antibody
products short name :
[SREBP-1c]
products name syn :
[ADD 1; bHLHd1; Class D basic helix-loop-helix protein 1; D630008H06; Processed sterol regulatory element-binding protein 1; SRBP1_HUMAN; SREBF 1; SREBF1; SREBP 1; SREBP 1c; SREBP-1; SREBP1; Sterol regulatory element binding protein 1; Sterol Regulatory Element Binding Transcription Factor 1/Protein 1; Sterol regulatory element binding transcription factor 1; Sterol regulatory element-binding transcription factor 1]
other names :
[sterol regulatory element-binding protein 1 isoform a; Sterol regulatory element-binding protein 1; sterol regulatory element-binding protein 1; sterol regulatory element binding transcription factor 1; Class D basic helix-loop-helix protein 1; bHLHd1]
products gene name :
[SREBP-1c]
other gene names :
[SREBF1; SREBF1; SREBP1; bHLHd1; BHLHD1; SREBP1; SREBP-1; bHLHd1]
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
1177
purity :
Immunogen affinity purified
concentration :
1mg/ml
storage stability :
Store at -20 degree C. Stable for 12 months from date of receipt.
tested application :
Western Blot (WB)
app notes :
WB: 1:500-1:2000
image1 heading :
Western Blot (WB)
image2 heading :
Western Blot (WB)
image3 heading :
Western Blot (WB)
other info1 :
Immunogen: A synthesized peptide derived from human SREBP-1c. Storage Buffer: Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
ncbi gi num :
52630419
ncbi acc num :
NP_001005291.1
ncbi gb acc num :
NM_001005291.2
uniprot acc num :
P36956
ncbi mol weight :
122kDa
ncbi pathways :
AMPK Signaling Pathway (198868); Activation Of Gene Expression By SREBP (SREBF) Pathway (685552); Adipogenesis Pathway (198832); Caspase Cascade In Apoptosis Pathway (137974); Cholesterol Biosynthesis Pathway (198809); Circadian Clock Pathway (187173); Developmental Biology Pathway (477129); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Id Signaling Pathway (198871); Insulin Signaling Pathway (83090)
ncbi summary :
This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017]
uniprot summary :
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').
size1 :
0.1 mg
price1 :
280 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!
related products
browse more products
questions and comments