p47 phox (Phospho-Ser345) Antibody | MyBioSource MBS852921 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

p47 phox (Phospho-Ser345) Antibody

catalog :

MBS852921

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS852921

products type :

Antibody

products full name :

p47 phox (Phospho-Ser345) Antibody

products short name :

p47 phox

products name syn :

47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-1; NCF-47K; NCF1; Neutrophil cytosol factor 1; Neutrophil cytosolic factor 1; Neutrophil NADPH oxidase factor 1; P47 phox; p47-phox

other names :

neutrophil cytosol factor 1; Neutrophil cytosol factor 1; neutrophil cytosol factor 1; NCF-1; NCF-47K; p47-phox; nox organizer 2; nox-organizing protein 2; NADPH oxidase organizer 2; 47 kDa neutrophil oxidase factor; neutrophil NADPH oxidase factor 1; SH3 and PX domain-containing protein 1A; 47 kDa autosomal chronic granulomatous disease protein; neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1); neutrophil cytosolic factor 1; 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; SH3 and PX domain-containing protein 1A; p47-phox

other gene names :

NCF1; NCF1; NCF1A; NOXO2; p47phox; SH3PXD1A; NOXO2; SH3PXD1A; NCF-1

uniprot entry name :

NCF1_HUMAN

host :

Rabbit

reactivity :

Human

sequence length :

390

specificity :

p47 phox (Phospho-Ser345) antibody detects endogenous levels of p47 phox only when phosphorylated at serine 345.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

1mg/ml

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:1000

other info1 :

Reactivity Note: Human (Identities = 100%, Positives = 100%)

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human p47 phox around the phosphorylation site of serine 345 (P-Q-SP-P-G). All Sites: Human: Ser345. Pathway: Phospho-specific. Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation on site.

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Volpp B.D., Proc. Natl. Acad. Sci. U.S.A. 86:7195-7199(1989). Lomax K.J., Science 245:409-412(1989). Rodaway A.R.F., Mol. Cell. Biol. 10:5388-5396(1990).

ncbi gi num :

528078313

ncbi acc num :

NP_000256.4

ncbi gb acc num :

NM_000265.5

uniprot acc num :

P14598

ncbi mol weight :

30,781 Da

ncbi pathways :

AGE/RAGE Pathway (698754); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Fc Gamma R-mediated Phagocytosis Pathway (114228); Fc Gamma R-mediated Phagocytosis Pathway (106590); Leishmaniasis Pathway (144181); Leishmaniasis Pathway (144028); Leukocyte Transendothelial Migration Pathway (83083); Leukocyte Transendothelial Migration Pathway (494); Osteoclast Differentiation Pathway (193147)

ncbi summary :

The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008]

uniprot summary :

p47phox: the 47-kilodalton cytosolic subunit of the multi-protein complex known as NADPH oxidase found in neutrophils. The holo-oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Contains 2 SH2 domains. Mutations in NCF1, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease. Protein type: EC 1.-.-.-; Oxidoreductase. Chromosomal Location of Human Ortholog: 7q11.23. Cellular Component: Golgi apparatus; extrinsic to membrane; rough endoplasmic reticulum; cell soma; dendrite; cytosol; NADPH oxidase complex. Molecular Function: protein binding; electron carrier activity; superoxide-generating NADPH oxidase activity; phosphatidylinositol-3,4-bisphosphate binding; SH3 domain binding; phosphoinositide binding. Biological Process: respiratory burst during defense response; respiratory burst; interaction with host; apoptosis; superoxide metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; leukotriene metabolic process; cell proliferation; antigen processing and presentation of peptide antigen via MHC class I; negative regulation of smooth muscle contraction; innate immune response; cellular defense response; antigen processing and presentation of exogenous peptide antigen via MHC class I; response to yeast; protein targeting to membrane; inflammatory response; vascular endothelial growth factor receptor signaling pathway; superoxide release; hydrogen peroxide biosynthetic process. Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-positive, Type I

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage