catalog number :
MBS8528976
products full name :
Phospho-PAR1 (Tyr420) Antibody
products short name :
[PAR1]
products name syn :
[CF2R; Coagulation factor II (thrombin) receptor; Coagulation factor II receptor; F2R; HTR; PAR 1; PAR-1; PAR1; PAR1_HUMAN; Protease activated receptor 1; Proteinase activated receptor 1; Proteinase-activated receptor 1; Thrombin receptor; TR]
other names :
[proteinase-activated receptor 1 isoform 2; Proteinase-activated receptor 1; proteinase-activated receptor 1; coagulation factor II thrombin receptor; Coagulation factor II receptor; Thrombin receptor]
products gene name :
[PAR1]
other gene names :
[F2R; F2R; TR; HTR; CF2R; PAR1; PAR-1; CF2R; PAR1; TR; PAR-1]
reactivity :
Human, Mouse, Rat
purity :
Purified rabbit serum by affinity purification via sequential chromatography on phospho-and non-phospho-peptide affinity columns.
form :
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20 degree C. Stable for 12 months from date of receipt.
tested application :
Western Blot (WB)
app notes :
WB: 1:500-1:2000
other info1 :
Immunogen: A synthesized peptide derived from human PAR1 around the phosphorylation site of Tyr420
ncbi acc num :
NP_001298242.1
ncbi gb acc num :
NM_001311313.1
ncbi pathways :
Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); Common Pathway Of Fibrin Clot Formation (1269371); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Endocytosis Pathway (102279); Endocytosis Pathway (102181); Formation Of Fibrin Clot (Clotting Cascade) Pathway (1269368)
ncbi summary :
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
uniprot summary :
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.