catalog number :
MBS8528938
products full name :
Phospho-Occludin (Ser507) Antibody
products short name :
[Occludin]
products name syn :
[BLCPMG; FLJ08163; FLJ18079; FLJ77961; FLJ94056; MGC34277; Occludin; OCLN_HUMAN; Tight junction protein occludin]
other names :
[occludin isoform a; Occludin; occludin; occludin]
products gene name :
[OCLN]
other gene names :
[OCLN; OCLN; BLCPMG; PTORCH1; PPP1R115]
reactivity :
Human, Mouse, Rat
purity :
Purified rabbit serum by affinity purification via sequential chromatography on phospho-and non-phospho-peptide affinity columns.
form :
Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCI, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20°C. Stable for 12 months from date of receipt.
tested application :
Western Blot (WB)
app notes :
WB: 1:500-1:2000
other info1 :
Immunogen: A synthesized peptide derived from human Occludin around the phosphorylation site of Ser507
ncbi acc num :
NP_001192183.1
ncbi gb acc num :
NM_001205254.1
ncbi pathways :
Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Hepatitis C Pathway (173973); Hepatitis C Pathway (173907); Leukocyte Transendothelial Migration Pathway (83083); Leukocyte Transendothelial Migration Pathway (494); Pathogenic Escherichia Coli Infection Pathway (83103); Pathogenic Escherichia Coli Infection Pathway (672459); Pathogenic Escherichia Coli Infection Pathway (516); TGF-beta Receptor Signaling Pathway (138024)
ncbi summary :
This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. [provided by RefSeq, Apr 2011]
uniprot summary :
May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions.