IL-6R Antibody | MyBioSource MBS852863 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

IL-6R Antibody

catalog :

MBS852863

quantity :

0.1 mg

price :

290 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS852863

products type :

Antibody

products full name :

IL-6R Antibody

products short name :

IL-6R

other names :

Homo sapiens interleukin 6 receptor (IL6R), transcript variant 1, mRNA; Interleukin-6 receptor subunit alpha; interleukin-6 receptor subunit alpha; IL-6R 1; CD126 antigen; membrane glycoprotein 80; IL-6 receptor subunit alpha; interleukin 6 receptor; IL-6R 1; Membrane glycoprotein 80; gp80; CD_antigen: CD126

products gene name :

IL-6R

other gene names :

IL6R; IL6R; IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; gp80

uniprot entry name :

IL6RA_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

4176

form :

Lyophilized anti-IL-6Rantibody purified by peptide affinity. column containing 1% BSA and. 0.02% NaN3

concentration :

100ug/200ul

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Peptide ELISA titer: 1:40,000-1:80,000. Western blot analysis: 1:200-1:500. Optimal dilutions/concentrations should be determined by the end user.

other info1 :

Source Note: Rabbit polyclonal IL-6R (1) antibody was raised against a 1 amino acid peptide from near the intermediate residues of human IL-6R protein. Reactivity Note: Not yet tested in other species.

other info2 :

Pathway: interleukin 6 receptor

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

(1) Briso,E.M., Dienz,O. and Rincon,M. Cutting edge: soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells. J. Immunol. 180 (11), 7102-7106 (2008).

ncbi gi num :

31317250

ncbi acc num :

NP_000556.1

ncbi gb acc num :

NM_000565.2

ncbi mol weight :

40,237 Da

ncbi pathways :

Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); HIF-1 Signaling Pathway (695200); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); IL-6 Signaling Pathway (198864); IL6-mediated Signaling Events Pathway (137932); Immune System Pathway (106386); Interleukin-6 Signaling Pathway (205111)

ncbi summary :

This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011]

uniprot summary :

IL6R: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, cytokine. Chromosomal Location of Human Ortholog: 1q21. Cellular Component: extracellular space; basolateral plasma membrane; apical plasma membrane; extracellular region; plasma membrane; interleukin-6 receptor complex. Molecular Function: protein binding; enzyme binding; interleukin-6 binding; interleukin-6 receptor binding; protein homodimerization activity; ciliary neurotrophic factor receptor activity; interleukin-6 receptor activity. Biological Process: negative regulation of collagen biosynthetic process; positive regulation of smooth muscle cell proliferation; cytokine and chemokine mediated signaling pathway; neutrophil mediated immunity; positive regulation of interleukin-6 production; positive regulation of leukocyte chemotaxis; defense response to Gram-negative bacterium; endocrine pancreas development; positive regulation of chemokine production; positive regulation of tyrosine phosphorylation of Stat3 protein; activation of NF-kappaB transcription factor; positive regulation of osteoblast differentiation; monocyte chemotaxis; defense response to Gram-positive bacterium; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of MAPKKK cascade; response to cytokine stimulus; positive regulation of cell proliferation; acute-phase response; negative regulation of interleukin-8 production; hepatic immune response. Disease: Interleukin 6, Serum Level Of, Quantitative Trait Locus; Soluble Interleukin-6 Receptor, Serum Level Of, Quantitative Trait Locus

size1 :

0.1 mg

price1 :

290 USD

more info or order :

MyBioSource product webpage