antibody

MMP12 (Cleaved-Glu106) Antibody

MBS852859

0.1 mg

215 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, enzyme immunoassay

Antibody

MMP12 (Cleaved-Glu106) Antibody

MMP12

Macrophage metalloelastase [Precursor]; EC 3.4.24.65; HME; Matrix metalloproteinase-12; MMP-12; Macrophage elastase; ME; MMP12; HME

macrophage metalloelastase preproprotein; Macrophage metalloelastase; macrophage metalloelastase; matrix metalloproteinase 12 (macrophage elastase); matrix metallopeptidase 12 (macrophage elastase); Macrophage elastase; ME; hME; Matrix metalloproteinase-12; MMP-12

MMP12

MMP12; MMP12; ME; HME; MME; MMP-12; HME; MME; ME; hME; MMP-12

MMP12_HUMAN

Rabbit

Human

470

MMP12 (Cleaved-Glu106) antibody detects endogenous levels of fragment of activated MMP12 resulting from cleavage adjacent to Glu106.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at -20 degree C for 1 year

Western Blot (WB), ELISA (EIA)

WB: 1:500~1:1000, ELISA: 1:20000

Immunogen: The antiserum was produced against synthesized peptide derived from human MMP12. Pathway: Cleaved-specific

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

Shapiro S.D., J. Biol. Chem. 268:23824-23829(1993). Gronski T.J. Jr., J. Biol. Chem. 272:12189-12194(1997). Lang R., J. Mol. Biol. 312:731-742(2001).

73858572

NP_002417.2

NM_002426.4

P39900

54,002 Da

Collagen Degradation Pathway (730309); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262); Matrix Metalloproteinases Pathway (198900)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

MMP12: May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1 site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. Belongs to the peptidase M10A family. Protein type: Secreted, signal peptide; EC 3.4.24.65; Protease; Secreted. Chromosomal Location of Human Ortholog: 11q22.3. Cellular Component: proteinaceous extracellular matrix; extracellular region. Molecular Function: zinc ion binding; metalloendopeptidase activity; endopeptidase activity; calcium ion binding. Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; positive regulation of epithelial cell proliferation involved in wound healing; proteolysis; wound healing, spreading of epidermal cells

0.1 mg

215 USD