catalog number :
MBS8527680
products full name :
Mouse Monoclonal Antibody to ACLY
products short name :
[ACLY]
products name syn :
[ACL; ATPCL; CLATP]
other names :
[ACLY, partial; ATP-citrate synthase; ATP-citrate synthase; ATP citrate lyase; ATP-citrate (pro-S-)-lyase; ACL; Citrate cleavage enzyme]
products gene name :
[ACLY]
other gene names :
[ACLY; ACLY; ACL; ATPCL; CLATP; ACL]
storage stability :
Store at -20°C /1 year.
tested application :
Recombinant Western Blot (RWB), Lysate Western Blot (LWB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)
app notes :
Western blot using Recombinant protein. Western blot using Cell lysate
image1 heading :
Immunohistochemical (IHC)
image2 heading :
Immunohistochemical (IHC)
other info1 :
Immunogen: 306-502
ncbi acc num :
JAO66211.1
ncbi pathways :
Amino Acid Metabolism Pathway (1471249); Butyrate-induced Histone Acetylation Pathway (1458221); ChREBP Activates Metabolic Gene Expression Pathway (1270114); Citrate Cycle (TCA Cycle) Pathway (82927); Citrate Cycle (TCA Cycle) Pathway (288); Fatty Acid Biosynthesis Pathway (198873); Fatty Acyl-CoA Biosynthesis Pathway (1270012); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (1270010); Immune System Pathway (1269170); Innate Immune System Pathway (1269203)
ncbi summary :
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]
uniprot summary :
ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.