product summary
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company name :
MyBioSource
product type :
antibody
product name :
Mouse Monoclonal Antibody to AlCAM
catalog :
MBS8527641
quantity :
0.1 mL
price :
280 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
[5B3A8]
reactivity :
human
application :
immunohistochemistry
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS8527641
products type :
Antibody
products full name :
Mouse Monoclonal Antibody to AlCAM
products short name :
[AlCAM]
products name syn :
[MEMD; CD166; FLJ38514; MGC71733]
other names :
[alcam; CD166 antigen; CD166 antigen; activated leukocyte cell adhesion molecule; Activated leukocyte cell adhesion molecule; CD_antigen: CD166]
products gene name :
[AlCAM]
other gene names :
[ALCAM; ALCAM; MEMD; CD166; ]
clonality :
Monoclonal
isotype :
IgG1
clone :
[5B3A8]
host :
Mouse
sequence length :
583
tested application :
Recombinant Western Blot (RWB), Lysate Western Blot (LWB), Immunohistochemistry (IHC)
other info1 :
Immunogen: 405-524
ncbi gi num :
886258
ncbi acc num :
AAB59499.1
ncbi mol weight :
65.1kDa
ncbi pathways :
Axon Guidance Pathway (105688); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Developmental Biology Pathway (477129); L1CAM Interactions Pathway (161003)
ncbi summary :
This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011]
uniprot summary :
Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons ().
size1 :
0.1 mL
price1 :
280 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

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