antibody

Mouse Monoclonal Antibody to ITK

MBS8527497

0.1 mL

280 USD

monoclonal

mouse

nonconjugated

[5G6A6]

ELISA, immunocytochemistry, flow cytometry, FACS, enzyme immunoassay

Antibody

Mouse Monoclonal Antibody to ITK

[ITK]

[EMT; LYK; PSCTK2; MGC126257; MGC126258]

[ITK; Tyrosine-protein kinase ITK/TSK; tyrosine-protein kinase ITK/TSK; IL2 inducible T cell kinase; Interleukin-2-inducible T-cell kinase; IL-2-inducible T-cell kinase; Kinase EMT; T-cell-specific kinase; Tyrosine-protein kinase Lyk]

[ITK]

[ITK; ITK; EMT; LYK; LPFS1; PSCTK2; EMT; LYK; IL-2-inducible T-cell kinase]

Monoclonal

IgG1

[5G6A6]

Mouse

620

Store at 4°C for long term storage store at -20°C.

ELISA (EIA), RWB, LWB, Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)

Immunogen: 2-120

399658

BAA02873.1

72kDa

Adaptive Immune System Pathway (366160); B Cell Receptor Signaling Pathway (198909); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class I PI3K Signaling Events Pathway (138022); FCERI Mediated Ca+2 Mobilization Pathway (833827); Fc Epsilon Receptor (FCERI) Signaling Pathway (833825); Fc-epsilon Receptor I Signaling In Mast Cells Pathway (138050); Generation Of Second Messenger Molecules Pathway (106417); Immune System Pathway (106386)

This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]

Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 ().

0.1 mL

280 USD