GluR2 (Phospho-Ser880) Antibody | MyBioSource MBS852728 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

GluR2 (Phospho-Ser880) Antibody

catalog :

MBS852728

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS852728

products type :

Antibody

products full name :

GluR2 (Phospho-Ser880) Antibody

products short name :

GluR2

products name syn :

GRIA2; GluR-2; GluR-B; GluR-K2; Glutamate receptor 2 precursor; Glutamate receptor ionotropic; AMPA 2

other names :

glutamate receptor 2 isoform 1; Glutamate receptor 2; glutamate receptor 2; gluR-2; gluR-B; AMPA-selective glutamate receptor 2; glutamate receptor, ionotropic, AMPA 2; AMPA-selective glutamate receptor 2; GluR-B; GluR-K2; Glutamate receptor ionotropic, AMPA 2; GluA2

products gene name :

GluR2

other gene names :

GRIA2; GRIA2; GLUR2; GLURB; GluA2; HBGR2; GluR-K2; GLUR2; GluR-2; GluA2

uniprot entry name :

GRIA2_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

883

specificity :

Glutamate receptor 2 (phospho-Ser880) antibody detects endogenous levels of Glutamate receptor 2 only when phosphorylated at serine 880.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

100ug/100ul

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:20000

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human Glutamate receptor 2 around the phosphorylation site of serine 880 (I-E-SP-V-K) (CYNVYGIESVKI). All Sites: Human: Ser880; Mouse: Ser880; Rat: Ser880. Pathway: Phospho-specific

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Kenneth J. Seidenman, J. Neurosci., Oct 2003; 23: 9220. Baosong Liu, J. Neurosci., May 2006; 26: 5309 - 5319. Jie Fu, J. Neurosci., Aug 2003; 23: 7592. Jose L. Perez, J. Neurosci., Aug 2001; 21: 5417.

ncbi gi num :

74275354

ncbi acc num :

NP_000817.2

ncbi gb acc num :

NM_000826.3

uniprot acc num :

P42262

ncbi mol weight :

93,775 Da

ncbi pathways :

Activation Of AMPA Receptors Pathway (106539); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); BDNF Signaling Pathway (712093); Circadian Entrainment Pathway (698773); Circadian Entrainment Pathway (699872); Cocaine Addiction Pathway (546258)

ncbi summary :

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG- Q- R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

GluR2: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA(quisqualate) glutamate kainate. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Channel, calcium; Membrane protein, integral. Chromosomal Location of Human Ortholog: 4q32.1. Cellular Component: postsynaptic membrane; synaptic vesicle; endoplasmic reticulum membrane; integral to plasma membrane; dendrite; plasma membrane; cell junction. Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity. Biological Process: synaptic transmission, glutamatergic; synaptic transmission; ionotropic glutamate receptor signaling pathway; signal transduction

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage