Histone H2A (Phospho-Thr121) Antibody | MyBioSource MBS852710 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Histone H2A (Phospho-Thr121) Antibody

catalog :

MBS852710

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS852710

products type :

Antibody

products full name :

Histone H2A (Phospho-Thr121) Antibody

products short name :

Histone H2A

products name syn :

H2A.1b; H2A/c; H2A/d; H2A/i; H2A/n; H2A/p; H2A1; H2AC; H2AFC; H2AFD ANDHIST1H2AL; H2AFI; H2AFN ANDHIST1H2AG; H2AFP; HIST1H2AI; HIST1H2AJ; HIST1H2AM; Histone H2A.c/d/i/n/p

other names :

histone H2A type 1; Histone H2A type 1; histone H2A type 1; H2A.1; histone 1, H2ai; H2A histone family, member C; histone cluster 1, H2ai; Histone H2A/p

other gene names :

HIST1H2AI; HIST1H2AG; H2A/c; H2AFC; H2AFP; H2A.1

uniprot entry name :

H2A1_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

130

specificity :

Histone H2A (Phospho-Thr121) antibody detects endogenous levels of Histone H2A only when phosphorylated at threonine 121.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Immunohistochemistry (IHC), ELISA (EIA)

app notes :

IHC: 1:50~1:100, ELISA: 1:1000

other info1 :

Reactivity Note: Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human Histone H2A around the phosphorylation site of threonine 121 (K-K-TP-E-S). All Sites: Human: Thr121; Mouse: Thr121; Rat: Thr121. Pathway: Phospho-specific

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Albig W., Hum. Genet. 101:284-294(1997). Albig W., Biol. Chem. 380:7-18(1999). Dobner T., DNA Seq. 1:409-413(1991). ----------------------------------------------------------------------------

ncbi gi num :

4504239

ncbi acc num :

NP_003500.1

ncbi gb acc num :

NM_003509.2

uniprot acc num :

P0C0S8

ncbi mol weight :

14,091 Da

ncbi pathways :

Alcoholism Pathway (585563); Alcoholism Pathway (587116); Chromatin Modifying Enzymes Pathway (941403); Chromatin Organization Pathway (941402); HATs Acetylate Histones Pathway (941404); HDACs Deacetylate Histones Pathway (1016170); RMTs Methylate Histone Arginines Pathway (1016172); Systemic Lupus Erythematosus Pathway (83122); Systemic Lupus Erythematosus Pathway (534)

ncbi summary :

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]

uniprot summary :

H2A.1: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H2A family. Protein type: DNA-binding. Chromosomal Location of Human Ortholog: 6p22.1. Cellular Component: nucleosome; nucleus. Molecular Function: protein binding; enzyme binding; DNA binding; protein heterodimerization activity

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage