antibody

Ceruloplasmin Antibody

MBS852670

0.1 mg

355 USD

monoclonal

mouse

nonconjugated

western blot, ELISA, enzyme immunoassay

Antibody

Ceruloplasmin Antibody

Ceruloplasmin

ceruloplasmin; Ceruloplasmin; ceruloplasmin; ceruloplasmin (ferroxidase); Ferroxidase

CP; CP; CP-2

CERU_HUMAN

Monoclonal

IgG2a

Mouse

1065

Anti-Ceruloplasmin recognizes recombinant protein Ceruloplasmin.

Each vial contains 100 ug IgG in 100 ul of citrate-tris-HCl buffer pH7.0 with 0.02% Proclin 300.

The antibody may be stored at -20 degree C for one year in its original formulation. Additionally, antibody may be stored at 2 degree C to 8 degree C for up to 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles of the diluted antibody.

ELISA (EIA), Western Blot (WB-Re)

Source Note: Purified mouse monoclonal antibody generated using E Coli expressed recombinant protein Ceruloplasmin as immunogen.

Immunogen: Recombinant protein corresponding to fragment(aa/933-1065) Ceruloplasmin.

Plant antibody

4557485

NP_000087.1

NM_000096.3

122,205 Da

HIF-1-alpha Transcription Factor Network Pathway (138045); Iron Uptake And Transport Pathway (187191); Metal Ion SLC Transporters Pathway (161066); Porphyrin And Chlorophyll Metabolism Pathway (83021); Porphyrin And Chlorophyll Metabolism Pathway (407); SLC-mediated Transmembrane Transport Pathway (119558); Transmembrane Transport Of Small Molecules Pathway (106572); Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway (119571)

The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]

CP: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense. Defects in CP are the cause of aceruloplasminemia (ACERULOP). It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances. Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2. Belongs to the multicopper oxidase family. Protein type: Oxidoreductase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.16.3.1; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 3q23-q25. Cellular Component: extracellular space; lysosomal membrane; extracellular region. Molecular Function: ferroxidase activity; copper ion binding; chaperone binding. Biological Process: cellular iron ion homeostasis; copper ion transport; transmembrane transport. Disease: Aceruloplasminemia

0.1 mg

355 USD