catalog number :
MBS852652
products full name :
TAF3 Antibody
products short name :
TAF3
products name syn :
Transcription initiation factor TFIID subunit 3; 140 kDa TATA box-binding protein-associated factor; TBP-associated factor 3; Transcription initiation factor TFIID 140 kDa subunit; TAF(II)140; TAF140; TAFII-140; TAFII140
other names :
transcription initiation factor TFIID subunit 3; Transcription initiation factor TFIID subunit 3; transcription initiation factor TFIID subunit 3; TAF(II)140; TBP-associated factor 3; RNA polymerase II transcription factor TAFII140; 140 kDa TATA box-binding protein-associated factor; transcription initiation factor TFIID 140 kDa subunit; TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa; 140 kDa TATA box-binding protein-associated factor; TBP-associated factor 3; Transcription initiation factor TFIID 140 kDa subunit; TAF(II)140; TAF140; TAFII-140; TAFII140
products gene name :
TAF3
other gene names :
TAF3; TAF3; TAF140; TAFII140; TAFII-140; TAF(II)140; TAF140; TAFII-140; TAFII140
uniprot entry name :
TAF3_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
TAF3 antibody detects endogenous levels of total TAF3 protein.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
storage stability :
Store at -20 degree C for 1 year
tested application :
Western Blot (WB), ELISA (EIA)
app notes :
WB: 1:500~1:1000, ELISA: 1:10000
other info2 :
Immunogen: The antiserum was produced against synthesized peptide derived from internal of human TAF3. Pathway: Transcription
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
Gangloff Y.G., Mol. Cell. Biol. 21:5109-5121(2001) [PubMed: 11438666]. Deloukas P., Nature 429:375-381(2004) [PubMed: 15164054]. Bechtel S., BMC Genomics 8:399-399(2007) [PubMed: 17974005]. -----------------------------------------------------------------------------------------------------------
ncbi acc num :
NP_114129.1
ncbi gb acc num :
NM_031923.3
ncbi mol weight :
103,582 Da
ncbi pathways :
Basal Transcription Factors Pathway (83038); Basal Transcription Factors Pathway (443); Disease Pathway (530764); Gene Expression Pathway (105937); HIV Infection Pathway (105983); HIV Life Cycle Pathway (105984); HIV Transcription Initiation Pathway (105998); Herpes Simplex Infection Pathway (377873); Herpes Simplex Infection Pathway (377865); Late Phase Of HIV Life Cycle Pathway (105995)
ncbi summary :
The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]).[supplied by OMIM, May 2009]
uniprot summary :
TAF140: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process. Belongs to the TAF3 family. Protein type: Transcription initiation complex. Chromosomal Location of Human Ortholog: 10p15.1. Cellular Component: nucleoplasm; transcription factor TFIID complex; nucleus. Molecular Function: protein binding; zinc ion binding; p53 binding. Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; viral reproduction; negative regulation of transcription factor activity; RNA elongation from RNA polymerase II promoter; gene expression; negative regulation of transcription from RNA polymerase II promoter; maintenance of protein localization in nucleus