antibody

Bcl-6 (Phospho-Ser333) Antibody

MBS852508

0.1 mg

215 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, enzyme immunoassay

Antibody

Bcl-6 (Phospho-Ser333) Antibody

Bcl-6

B-cell CLL/lymphoma 6; B-cell lymphoma 6 protein; B-cell lymphoma 6 protein homolog; Bcl-5; Bcl5; Bcl6; LAZ-3 protein; LAZ3; Zinc finger protein 51; ZNF51

B-cell lymphoma 6 protein isoform 1; B-cell lymphoma 6 protein; B-cell lymphoma 6 protein; BCL-5; BCL-6; protein LAZ-3; zinc finger protein 51; B-cell lymphoma 5 protein; B-cell lymphoma 6 protein transcript; zinc finger transcription factor BCL6S; cys-his2 zinc finger transcription factor; zinc finger and BTB domain-containing protein 27; lymphoma-associated zinc finger gene on chromosome 3; B-cell CLL/lymphoma 6; B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51

Bcl-6

BCL6; BCL6; BCL5; LAZ3; BCL6A; ZNF51; ZBTB27; BCL5; LAZ3; ZBTB27; ZNF51; BCL-6; BCL-5

BCL6_HUMAN

Rabbit

Human, Mouse, Rat

706

Bcl-6 (Phospho-Ser333) antibody detects endogenous levels of Bcl-6 only when phosphorylated at serine 333.

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1mg/ml

Store at -20 degree C for 1 year

Western Blot (WB), ELISA (EIA)

WB: 1:500~1:1000, ELISA: 1:1000

Reactivity Note: Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human Bcl-6 around the phosphorylation site of serine 333 (P-Q-SP-P-Q). All Sites: Human: Ser333; Mouse: Ser334; Rat: Ser334. Pathway: Phospho-specific

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

Kerckaert J.-P., Nat. Genet. 5:66-70(1993). Ye B.H., Science 262:747-750(1993). Miki T., Blood 83:26-32(1994). ----------------------------------------------------------------------------

195927002

NP_001124317.1

NM_001130845.1

P41182

72,367 Da

B Cell Receptor Signaling Pathway (198909); DNA Damage Response (only ATM Dependent) Pathway (198827); Direct P53 Effectors Pathway (137939); FoxO Family Signaling Pathway (138036); FoxO Signaling Pathway (921162); IL4-mediated Signaling Events Pathway (137933); Signaling Events Mediated By HDAC Class II Pathway (138062); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Bcl-6: a zinc finger transcription factor and contains an N-terminal BTB/POZ domain. A sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. Mediates transcriptional repression and interacts with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The gene is frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Protein type: Oncoprotein; Transcription factor; C2H2-type zinc finger protein. Chromosomal Location of Human Ortholog: 3q27. Cellular Component: replication fork; nucleus. Molecular Function: protein binding; chromatin DNA binding; sequence-specific DNA binding; metal ion binding; chromatin binding; transcription factor activity. Biological Process: erythrocyte development; positive regulation of apoptosis; regulation of memory T cell differentiation; cell morphogenesis; negative regulation of transcription from RNA polymerase II promoter; Rho protein signal transduction; negative regulation of cell proliferation; negative regulation of isotype switching to IgE isotypes; positive regulation of histone deacetylation; germinal center formation; positive regulation of B cell proliferation; negative regulation of mast cell cytokine production; inflammatory response; negative regulation of T-helper 2 cell differentiation; regulation of immune response; T-helper 2 type immune response; transcription, DNA-dependent; positive regulation of cell motility; negative regulation of cell-matrix adhesion; regulation of germinal center formation; negative regulation of Rho protein signal transduction; protein import into nucleus, translocation; B cell differentiation; regulation of inflammatory response; negative regulation of Notch signaling pathway; spermatogenesis; negative regulation of cell growth; positive regulation of neuron differentiation; negative regulation of transcription, DNA-dependent; actin cytoskeleton organization and biogenesis; response to DNA damage stimulus; negative regulation of B cell apoptosis

0.1 mg

215 USD