catalog number :
MBS8524809
products full name :
PP2A-B56-alpha Polyclonal Antibody
products short name :
[PP2A-B56-alpha]
products name syn :
[PPP2R5A; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; PP2A B subunit isoform B'- alpha; PP2A B subunit isoform B56-alpha; PP2A B subunit isoform PR61-alpha; PR61alpha; PP2A B subunit isoform R5- alpha.]
other names :
[serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform 2; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; protein phosphatase 2 regulatory subunit B'alpha; PP2A B subunit isoform B'-alpha; PP2A B subunit isoform B56-alpha; PP2A B subunit isoform PR61-alpha; PR61alpha; PP2A B subunit isoform R5-alpha]
products gene name :
[PP2A-B56-alpha]
other gene names :
[PPP2R5A; PPP2R5A; B56A; PR61A; B56alpha; PR61alpha]
reactivity :
Human, Mouse, Rat
specificity :
PP2A-B56-alpha Polyclonal Antibody detects endogenous levels of PP2A-B56-alpha protein.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
storage stability :
Store at -20°C/1 year
tested application :
Western Blot (WB), ELISA (EIA)
app notes :
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested
in other applications.
other info1 :
Immunogen: Synthesized peptide derived from the Internal region of human PP2A-B56-alpha. at AA rangle: 290-370
ncbi acc num :
NP_001186685.1
ncbi gb acc num :
NM_001199756.1
ncbi pathways :
Adaptive Immune System Pathway (366160); Beta-catenin Phosphorylation Cascade Pathway (106512); C-MYC Pathway (169344); CTLA4 Inhibitory Signaling Pathway (119556); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Costimulation By The CD28 Family Pathway (119552); Degradation Of Beta-catenin By The Destruction Complex Pathway (106511); Dopaminergic Synapse Pathway (469199); Dopaminergic Synapse Pathway (469185)
ncbi summary :
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
uniprot summary :
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.