product summary
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company name :
MyBioSource
product type :
antibody
product name :
AMOTL2 Antibody
catalog :
MBS852452
quantity :
0.1 mg
price :
290 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS852452
products type :
Antibody
products full name :
AMOTL2 Antibody
products short name :
AMOTL2
other names :
angiomotin-like protein 2 isoform 2; Angiomotin-like protein 2; angiomotin-like protein 2; Leman coiled-coil protein; angiomotin like 2; Leman coiled-coil protein; LCCP
products gene name :
AMOTL2
other gene names :
AMOTL2; AMOTL2; LCCP; KIAA0989; LCCP
uniprot entry name :
AMOL2_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human
sequence length :
780
form :
Lyophilized AMOTL2 antibody purified by protein affinity column containing 1% BSA and 0.02% NaN3
concentration :
100ug/200ul
storage stability :
Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at -20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
ELISA titer: 1:20,000-1:80,000. Western blot analysis: 1:500-1:1,000. Immunohistochemistry: 1:100-1:500. Optimal dilutions/concentrations should be determined by the end user.
other info1 :
Source Note: Rabbit polyclonal AMOTL2 (1) antibody was raised against a recombinate human AMOTL2 protein 6-235aa (BC011454). Reactivity Note: Predicted: Mouse, Rat; Not yet tested in other species.
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
ncbi gi num :
32484977
ncbi acc num :
BC011454
ncbi gb acc num :
NM_016201.3
ncbi mol weight :
91,817 Da
ncbi pathways :
Signal Transduction Pathway (477114); Signaling By Hippo Pathway (576275)
ncbi summary :
Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
uniprot summary :
AMOTL2: Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC. Belongs to the angiomotin family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Cell adhesion. Chromosomal Location of Human Ortholog: 3q21-q22. Cellular Component: recycling endosome; tight junction; apical plasma membrane; cytoplasmic vesicle; cytosol. Molecular Function: identical protein binding; protein binding. Biological Process: Wnt receptor signaling pathway
size1 :
0.1 mg
price1 :
290 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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