Integrin beta 1 (Phospho-Thr789) Antibody | MyBioSource MBS852395 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Integrin beta 1 (Phospho-Thr789) Antibody

catalog :

MBS852395

quantity :

0.1 mg

price :

215 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS852395

products type :

Antibody

products full name :

Integrin beta 1 (Phospho-Thr789) Antibody

products short name :

Integrin beta 1

products name syn :

Integrin b1 (Phospho-Thr789) Antibody; CD29; FNRB; Fibronectin receptor beta subunit; ITB1; Integrin VLA-4 beta subunit; Integrin beta-1 precursor; integrin beta-1

other names :

integrin beta-1 isoform 1A; Integrin beta-1; integrin beta-1; glycoprotein IIa; integrin VLA-4 beta subunit; very late activation protein, beta polypeptide; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; VLA-4 subunit beta; CD_antigen: CD29

other gene names :

ITGB1; ITGB1; CD29; FNRB; MDF2; VLAB; GPIIA; MSK12; VLA-BETA; FNRB; MDF2; MSK12; GPIIA

uniprot entry name :

ITB1_HUMAN

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

798

specificity :

Integrin beta1 (Phospho-Thr789) antibody detects endogenous levels of Integrin beta1 only when phosphorylated at threonine 789.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

storage stability :

Store at -20 degree C for 1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

app notes :

WB: 1:500~1:1000, IHC: 1:50~1:100, IF: 1:100~1:500, ELISA: 1:1000

other info2 :

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human Integrin beta1 around the phosphorylation site of threonine 789 (V-T-TP-V-V). All Sites: Human: Tyr789; Mouse: Tyr789; Rat: Tyr790. Pathway: Phospho-specific

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

products references :

Argraves W.S., J. Cell Biol. 105:1183-1190(1987). Balzac F., J. Cell Biol. 121:171-178(1993). Balzac F., J. Cell Biol. 127:557-565(1994).

ncbi gi num :

19743813

ncbi acc num :

NP_002202.2

ncbi gb acc num :

NM_002211.3

uniprot acc num :

P05556

ncbi mol weight :

88,884 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Arf6 Trafficking Events Pathway (137954); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); Bacterial Invasion Of Epithelial Cells Pathway (149807)

ncbi summary :

Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

ITGB1: an integral membrane protein that heterodimerizes with an alpha-3 chain, forming a receptor for many extracellular-matrix proteins including fibronectin, laminin, collagen, epiligrin and thrombospondin. Beta 1 integrins recognize the amino-acid motif RGD in a wide array of ligands. Five alternatively spliced variants with alternate carboxy termini have been described. Two alternatively spliced isoforms have been described. Isoform beta-1a is widely expressed; other isoforms are generally expressed with a more restricted distribution. Isoform beta-1b is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoforms beta-1c and beta-1c-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-c-2, rather than isoform beta-1c, is selectively expressed in primary t-cells. Isoform beta-1c is expressed in nonproliferating and differentiated prostate gland epithelial cells. Isoform beta-1d is expressed specifically in striated muscle (skeletal and cardiac muscle). Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis; Cell surface; Receptor, misc. Chromosomal Location of Human Ortholog: 10p11.2. Cellular Component: cell surface; focal adhesion; acrosome; dendritic spine; lipid raft; ruffle; recycling endosome; membrane; hemidesmosome; lamellipodium; cytoplasm; plasma membrane; melanosome; basement membrane; neuromuscular junction; integrin complex; sarcolemma; receptor complex; external side of plasma membrane; filopodium; cleavage furrow. Molecular Function: protein domain specific binding; protease binding; metal ion binding; laminin binding; alpha-actinin binding; actin binding; peptide binding; protein kinase binding; viral receptor activity; integrin binding; protein binding; protein heterodimerization activity; fibronectin binding; cell adhesion molecule binding; glycoprotein binding. Biological Process: extracellular matrix organization and biogenesis; maternal process involved in pregnancy; axon extension; regulation of cell cycle; positive regulation of apoptosis; mesodermal cell differentiation; positive regulation of endocytosis; cardiac muscle cell differentiation; leukocyte adhesion; transforming growth factor beta receptor signaling pathway; germ cell migration; tissue homeostasis; response to drug; dendrite morphogenesis; protein transport within lipid bilayer; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of neuron differentiation; cell migration during sprouting angiogenesis; B cell differentiation; cell-cell adhesion mediated by integrin; response to activity; leukocyte migration; regulation of G-protein coupled receptor protein signaling pathway; G1/S transition of mitotic cell cycle; axon guidance; entry of virus into host cell; cell-matrix adhesion; cell fate specification; negative regulation of cell proliferation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; visual learning; negative regulation of cell projection organization and biogenesis; integrin-mediated signaling pathway; cell migration; regulation of immune response; in utero embryonic development; sarcomere organization; cell-substrate adhesion; formation of radial glial scaffolds; cellular calcium ion homeostasis; heterotypic cell-cell adhesion; negative regulation of Rho protein signal transduction; stress fiber formation; calcium-independent cell-matrix adhesion; cellular defense response; homophilic cell adhesion; leukocyte tethering or rolling; blood coagulation; positive regulation of cell migration

size1 :

0.1 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage