antibody

IL11RA Antibody

MBS852315

0.1 mg

290 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

IL11RA Antibody

IL11RA

interleukin-11 receptor subunit alpha; Interleukin-11 receptor subunit alpha; interleukin-11 receptor subunit alpha; IL-11R subunit alpha; IL-11 receptor subunit alpha; interleukin-11 receptor alpha chain; interleukin 11 receptor, alpha

IL11RA

IL11RA; IL11RA; CRSDA; IL-11 receptor subunit alpha; IL-11R subunit alpha; IL-11R-alpha; IL-11RA

I11RA_HUMAN

Polyclonal

Rabbit

Human

422

Lyophilized IL11RA antibody purified by protein affinity column containing 1% BSA and 0.02% NaN3

100ug/200ul

Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at -20 degree C after reconstitution. Avoid repeated freeze/defrost cycles

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

ELISA titer: 1:20,000-1:80,000. Western blot analysis: 1:1,000-1:2,000. Immunohistochemistry: 1:100-1:500. Optimal dilutions/concentrations should be determined by the end use

Source Note: Rabbit polyclonal IL11RA (1) antibody was raised against a recombinate human IL11RA protein 177-370aa (BC003110). Reactivity Note: Predicted: Mouse, Rat; Not yet tested in other species.

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

218505839

NP_001136256.1

NM_001142784.2

41,842 Da

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Interleukin-11 Signaling Pathway (698753); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488)

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

IL11RA: Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Defects in IL11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 9p13. Cellular Component: integral to plasma membrane. Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; signal transducer activity; transmembrane receptor activity. Biological Process: cytokine and chemokine mediated signaling pathway; developmental process; signal transduction; embryo implantation. Disease: Craniosynostosis And Dental Anomalies

0.1 mg

290 USD