antibody

RKIP Antibody

MBS852226

0.1 mg

355 USD

monoclonal

mouse

nonconjugated

western blot, ELISA, enzyme immunoassay

Antibody

RKIP Antibody

RKIP

phosphatidylethanolamine-binding protein 1 preproprotein; Phosphatidylethanolamine-binding protein 1; phosphatidylethanolamine-binding protein 1; neuropolypeptide h3; prostatic binding protein; prostatic-binding protein; raf kinase inhibitor protein; Raf kinase inhibitory protein; epididymis luminal protein 210; epididymis secretory protein Li 34; hippocampal cholinergic neurostimulating peptide; phosphatidylethanolamine binding protein 1; HCNPpp; Neuropolypeptide h3; Prostatic-binding protein; Raf kinase inhibitor protein; RKIP

RKIP

PEBP1; PEBP1; PBP; HCNP; PEBP; RKIP; HCNPpp; PEBP-1; HEL-210; HEL-S-34; PBP; PEBP; PEBP-1; RKIP; HCNP

PEBP1_HUMAN

Monoclonal

IgG2a

Mouse

187

Anti-RKIP recognizes RKIP expression in SW480 whole cell lysate.

Each vial contains 100 ug IgG in 100 ul of citrate-tris-HCl buffer pH7.0 with 0.02% Proclin 300.

The antibody may be stored at -20 degree C for one year in its original formulation. Additionally, antibody may be stored at 2 degree C to 8 degree C for up to 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles of the diluted antibody.

ELISA (EIA), Western Blot (WB-Re), Western Blot (WB-Ce)

Source Note: Purified mouse monoclonal antibody generated using E Coli expressed recombinant protein RKIP as immunogen.

Immunogen: Recombinant protein corresponding to full length RKIP.

Plant antibody

4505621

NP_002558.1

NM_002567.2

21,057 Da

Aurora B Signaling Pathway (138080); EGFR1 Signaling Pathway (198782); ErbB1 Downstream Signaling Pathway (138057); TNF-alpha/NF-kB Signaling Pathway (198884)

This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]

RKIP: a metastasis suppressor that regulates extracellular matrix remodeling and tumor survival. Binds to and inhibits Raf-1. Phosphorylation by classic and atypical but not novel PKC isoforms dissociates this complex, relieving inhibition of the Raf/MAP kinase signaling cascade. Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. Cleaved into hippocampal cholinergic neurostimulating peptide (HCMP) that appears to be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Expressed in brain. Increased expression in aged senescence-accelerated mice. Protein type: Protein kinase, regulatory subunit; Lipid-binding. Chromosomal Location of Human Ortholog: 12q24.23. Cellular Component: cytoplasm; nucleus. Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; phosphatidylethanolamine binding; protein kinase binding; ATP binding

0.1 mg

355 USD