hsp60 Antibody | MyBioSource MBS852215 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

hsp60 Antibody

catalog :

MBS852215

quantity :

0.1 mg

price :

290 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS852215

products type :

Antibody

products full name :

hsp60 Antibody

products short name :

hsp60

other names :

Homo sapiens heat shock 60kDa protein 1 (chaperonin) (HSPD1), transcript variant 1, mRNA; 60 kDa heat shock protein, mitochondrial; 60 kDa heat shock protein, mitochondrial; chaperonin 60; 60 kDa chaperonin; heat shock protein 65; P60 lymphocyte protein; mitochondrial matrix protein P1; short heat shock protein 60 Hsp60s1; heat shock 60kDa protein 1 (chaperonin); 60 kDa chaperonin; Chaperonin 60; CPN60; Heat shock protein 60; HSP-60; Hsp60; HuCHA60; Mitochondrial matrix protein P1; P60 lymphocyte protein

products gene name :

hsp60

other gene names :

HSPD1; HSPD1; HLD4; CPN60; GROEL; HSP60; HSP65; SPG13; HSP-60; HuCHA60; HSP60; CPN60; HSP-60; Hsp60

uniprot entry name :

CH60_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

2339

form :

Lyophilized anti-hsp60 antibody purified by peptide affinity column containing 2% BSA and 0.02% NaN3

concentration :

100ug/200ul

storage stability :

Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at -20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Peptide ELISA titer: 1:40,000-1:80,000. Western blot analysis: 1:200-1,000. Immunohistochemistry: 1:50-200. Optimal dilutions/concentrations should be determined by the end user.

other info1 :

Source Note: Rabbit polyclonal hsp60 (1) antibody was raised against a peptide near the intermediate residues of human hsp60 protein. Reactivity Note: Not yet tested in other species.

products categories :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

ncbi gi num :

41399283

ncbi acc num :

NP_002147.2

ncbi gb acc num :

NM_002156

ncbi mol weight :

17,100 Da

ncbi pathways :

Legionellosis Pathway (469200); Legionellosis Pathway (469186); Metabolism Of Proteins Pathway (106230); Mitochondrial Protein Import Pathway (576261); RNA Degradation Pathway (117291); RNA Degradation Pathway (116127); SIDS Susceptibility Pathways (198901); Tuberculosis Pathway (213780); Tuberculosis Pathway (213743); Type I Diabetes Mellitus Pathway (83095)

ncbi summary :

This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]

uniprot summary :

HSP60: Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. Interacts with HRAS. Interacts with HBV protein X and HTLV-1 protein p40tax. Belongs to the chaperonin (HSP60) family. Protein type: Mitochondrial; Chaperone. Chromosomal Location of Human Ortholog: 2q33.1. Cellular Component: extracellular space; protein complex; cell surface; mitochondrion; early endosome; coated pit; cytosol; secretory granule; membrane; mitochondrial matrix; mitochondrial inner membrane; cytoplasm; plasma membrane; lipopolysaccharide receptor complex; cyclin-dependent protein kinase activating kinase holoenzyme complex. Molecular Function: protein binding; p53 binding; lipopolysaccharide binding; chaperone binding; ubiquitin protein ligase binding; double-stranded RNA binding; ATPase activity; unfolded protein binding; DNA replication origin binding; ATP binding; single-stranded DNA binding. Biological Process: B cell proliferation; caspase activation; viral reproduction; T cell activation; protein stabilization; B cell activation; positive regulation of apoptosis; positive regulation of interleukin-12 production; protein maturation; isotype switching to IgG isotypes; positive regulation of interleukin-6 production; B cell cytokine production; response to unfolded protein; positive regulation of interleukin-10 production; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interferon-gamma production; de novo protein folding; protein refolding; positive regulation of T cell activation; positive regulation of T cell mediated immune response to tumor cell; chaperone-mediated protein complex assembly; positive regulation of interferon-alpha production; negative regulation of apoptosis; positive regulation of macrophage activation. Disease: Spastic Paraplegia 13, Autosomal Dominant; Leukodystrophy, Hypomyelinating, 4

size1 :

0.1 mg

price1 :

290 USD

more info or order :

MyBioSource product webpage