catalog number :
MBS852111
products full name :
AMH Antibody
products short name :
AMH
other names :
muellerian-inhibiting factor; Muellerian-inhibiting factor; muellerian-inhibiting factor; anti-Muellerian hormone; Mullerian inhibiting factor; Mullerian inhibiting substance; muellerian-inhibiting substance; anti-Mullerian hormone; Anti-Muellerian hormone; AMH; Muellerian-inhibiting substance; MIS
other gene names :
AMH; AMH; MIF; MIS; MIF; AMH; MIS
uniprot entry name :
MIS_HUMAN
form :
Lyophilized anti-AMH Antibody purified by protein A column containing 0.02% NaN3.
concentration :
100ug/200ul
tested application :
Western Blot (WB)
app notes :
Peptide ELISA titer: 1:10,000-1:40,000. Western blot analysis: 1:1,000-1:2,000. Optimal dilutions/concentrations should be determined by the end user.
other info1 :
Source Note: Rabbit polyclonal AMH(1) antibody was raised against a 16 amino acid peptide from near the C terminal residues of human AMH protein. Reactivity Note: Not yet tested in other species.
other info2 :
Pathway: anti-Mullerian hormone
products categories :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
products references :
(1) Legeai,L.,Lefevre,G.,Vigier,B.et,al A monoclonal antibody against human testicular anti-mullerian hormone Am J Reprod Immunol Microbiol.1988;18(2):39-43.
ncbi acc num :
NP_000470.2
ncbi gb acc num :
NM_000479.3
ncbi mol weight :
59,195 Da
ncbi pathways :
ALK2 Signaling Events Pathway (137983); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); TGF-beta Signaling Pathway (83064); TGF-beta Signaling Pathway (475); CAMP Signaling Pathway (1017634); CAMP Signaling Pathway (1019520)
ncbi summary :
Anti-Mullerian hormone is a member of the transforming growth factor-beta gene family which mediates male sexual differentiation. Anti-Mullerian hormone causes the regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes. Some mutations in the anti-Mullerian hormone result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2008]
uniprot summary :
AMH: This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin. Defects in AMH are the cause of persistent Muellerian duct syndrome type 1 (PMDS1). PMDS1 is a form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males. Belongs to the TGF-beta family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: extracellular space; cytoplasm; extracellular region. Molecular Function: growth factor activity; hormone activity; transforming growth factor beta receptor binding; receptor binding. Biological Process: sex determination; response to drug; Mullerian duct regression; cell-cell signaling; gonadal mesoderm development; preantral ovarian follicle growth; response to organic cyclic substance; sex differentiation; urogenital system development; activation of NF-kappaB transcription factor; aging. Disease: Persistent Mullerian Duct Syndrome, Types I And Ii